L2HGDH-MAP4K5 Fusion FISH Probe
The L2HGDH-MAP4K5 Fusion FISH Probe is used to confirm a fusion of the L2HGDH and MAP4K5 genes. The fusion of the L2HGDH and MAP4K5 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| L2HGDH-MAP4K5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| L2HGDH-MAP4K5-20-RERE | 20 (40 μL) | 200 μL |
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| L2HGDH-MAP4K5-20-REOR | 20 (40 μL) | 200 μL |
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| L2HGDH-MAP4K5-20-REGO | 20 (40 μL) | 200 μL |
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| L2HGDH-MAP4K5-20-REGR | 20 (40 μL) | 200 μL |
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| L2HGDH-MAP4K5-20-REAQ | 20 (40 μL) | 200 μL |
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| L2HGDH-MAP4K5-20-ORRE | 20 (40 μL) | 200 μL |
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| L2HGDH-MAP4K5-20-OROR | 20 (40 μL) | 200 μL |
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| L2HGDH-MAP4K5-20-ORGO | 20 (40 μL) | 200 μL |
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| L2HGDH-MAP4K5-20-ORAQ | 20 (40 μL) | 200 μL |
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| L2HGDH-MAP4K5-20-GORE | 20 (40 μL) | 200 μL |
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| L2HGDH-MAP4K5-20-GOOR | 20 (40 μL) | 200 μL |
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| L2HGDH-MAP4K5-20-GOGO | 20 (40 μL) | 200 μL |
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| L2HGDH-MAP4K5-20-GOGR | 20 (40 μL) | 200 μL |
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| L2HGDH-MAP4K5-20-GOAQ | 20 (40 μL) | 200 μL |
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| L2HGDH-MAP4K5-20-GRRE | 20 (40 μL) | 200 μL |
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| L2HGDH-MAP4K5-20-GROR | 20 (40 μL) | 200 μL |
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| L2HGDH-MAP4K5-20-GRGO | 20 (40 μL) | 200 μL |
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| L2HGDH-MAP4K5-20-GRGR | 20 (40 μL) | 200 μL |
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| L2HGDH-MAP4K5-20-GRAQ | 20 (40 μL) | 200 μL |
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| L2HGDH-MAP4K5-20-AQRE | 20 (40 μL) | 200 μL |
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| L2HGDH-MAP4K5-20-AQOR | 20 (40 μL) | 200 μL |
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| L2HGDH-MAP4K5-20-AQGO | 20 (40 μL) | 200 μL |
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| L2HGDH-MAP4K5-20-AQGR | 20 (40 μL) | 200 μL |
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| L2HGDH-MAP4K5-20-AQAQ | 20 (40 μL) | 200 μL |
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MAP4K5 Gene Summary
This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Mitogen-activated Protein Kinase Kinase Kinase Kinase 5
Chromosome: CHR14: 50885210 -50999376
Locus: 14q22.1
L2HGDH Gene Summary
This gene encodes L-2-hydroxyglutarate dehydrogenase, a FAD-dependent enzyme that oxidizes L-2-hydroxyglutarate to alpha-ketoglutarate in a variety of mammalian tissues. Mutations in this gene cause L-2-hydroxyglutaric aciduria, a rare autosomal recessive neurometabolic disorder resulting in moderate to severe cognitive disability. [provided by RefSeq, Jul 2008]
Gene Name: L-2-hydroxyglutarate Dehydrogenase
Chromosome: CHR14: 50709151 -50778947
Locus: 14q21.3
Gene Diseases
The L2HGDH MAP4K5 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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