KRT6A-STAT6 Fusion FISH Probe
The KRT6A-STAT6 Fusion FISH Probe is used to confirm a fusion of the KRT6A and STAT6 genes. The fusion of the KRT6A and STAT6 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| KRT6A-STAT6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| KRT6A-STAT6-20-RERE | 20 (40 μL) | 200 μL |
|
|
| KRT6A-STAT6-20-REOR | 20 (40 μL) | 200 μL |
|
|
| KRT6A-STAT6-20-REGO | 20 (40 μL) | 200 μL |
|
|
| KRT6A-STAT6-20-REGR | 20 (40 μL) | 200 μL |
|
|
| KRT6A-STAT6-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| KRT6A-STAT6-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| KRT6A-STAT6-20-OROR | 20 (40 μL) | 200 μL |
|
|
| KRT6A-STAT6-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| KRT6A-STAT6-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| KRT6A-STAT6-20-GORE | 20 (40 μL) | 200 μL |
|
|
| KRT6A-STAT6-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| KRT6A-STAT6-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| KRT6A-STAT6-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| KRT6A-STAT6-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| KRT6A-STAT6-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| KRT6A-STAT6-20-GROR | 20 (40 μL) | 200 μL |
|
|
| KRT6A-STAT6-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| KRT6A-STAT6-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| KRT6A-STAT6-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| KRT6A-STAT6-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| KRT6A-STAT6-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| KRT6A-STAT6-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| KRT6A-STAT6-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| KRT6A-STAT6-20-AQAQ | 20 (40 μL) | 200 μL |
|
KRT6A Gene Summary
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. In addition, peptides from the C-terminal region of the protein have antimicrobial activity against bacterial pathogens. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Oct 2014]
Gene Name: Keratin 6A
Chromosome: CHR12: 52880957 -52887181
Locus: 12q13.13
STAT6 Gene Summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Name: Signal Transducer And Activator Of Transcription 6
Chromosome: CHR12: 57489186 -57505196
Locus: 12q13.3
Gene Diseases
The KRT6A STAT6 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|