KRT6A-ERBB3 Fusion FISH Probe
The KRT6A-ERBB3 Fusion FISH Probe is used to confirm a fusion of the KRT6A and ERBB3 genes. The fusion of the KRT6A and ERBB3 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KRT6A-ERBB3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KRT6A-ERBB3-20-RERE | 20 (40 μL) | 200 μL |
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| KRT6A-ERBB3-20-REOR | 20 (40 μL) | 200 μL |
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| KRT6A-ERBB3-20-REGO | 20 (40 μL) | 200 μL |
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| KRT6A-ERBB3-20-REGR | 20 (40 μL) | 200 μL |
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| KRT6A-ERBB3-20-REAQ | 20 (40 μL) | 200 μL |
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| KRT6A-ERBB3-20-ORRE | 20 (40 μL) | 200 μL |
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| KRT6A-ERBB3-20-OROR | 20 (40 μL) | 200 μL |
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| KRT6A-ERBB3-20-ORGO | 20 (40 μL) | 200 μL |
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| KRT6A-ERBB3-20-ORAQ | 20 (40 μL) | 200 μL |
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| KRT6A-ERBB3-20-GORE | 20 (40 μL) | 200 μL |
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| KRT6A-ERBB3-20-GOOR | 20 (40 μL) | 200 μL |
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| KRT6A-ERBB3-20-GOGO | 20 (40 μL) | 200 μL |
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| KRT6A-ERBB3-20-GOGR | 20 (40 μL) | 200 μL |
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| KRT6A-ERBB3-20-GOAQ | 20 (40 μL) | 200 μL |
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| KRT6A-ERBB3-20-GRRE | 20 (40 μL) | 200 μL |
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| KRT6A-ERBB3-20-GROR | 20 (40 μL) | 200 μL |
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| KRT6A-ERBB3-20-GRGO | 20 (40 μL) | 200 μL |
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| KRT6A-ERBB3-20-GRGR | 20 (40 μL) | 200 μL |
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| KRT6A-ERBB3-20-GRAQ | 20 (40 μL) | 200 μL |
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| KRT6A-ERBB3-20-AQRE | 20 (40 μL) | 200 μL |
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| KRT6A-ERBB3-20-AQOR | 20 (40 μL) | 200 μL |
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| KRT6A-ERBB3-20-AQGO | 20 (40 μL) | 200 μL |
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| KRT6A-ERBB3-20-AQGR | 20 (40 μL) | 200 μL |
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| KRT6A-ERBB3-20-AQAQ | 20 (40 μL) | 200 μL |
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ERBB3 Gene Summary
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Gene Name: Erb-b2 Receptor Tyrosine Kinase 3
Chromosome: CHR12: 56473808 -56497291
Locus: 12q13.2
KRT6A Gene Summary
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. In addition, peptides from the C-terminal region of the protein have antimicrobial activity against bacterial pathogens. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Oct 2014]
Gene Name: Keratin 6A
Chromosome: CHR12: 52880957 -52887181
Locus: 12q13.13
Gene Diseases
The KRT6A ERBB3 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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