KRT6A-CXCR5 Fusion FISH Probe
The KRT6A-CXCR5 Fusion FISH Probe is used to confirm a fusion of the KRT6A and CXCR5 genes. The fusion of the KRT6A and CXCR5 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KRT6A-CXCR5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KRT6A-CXCR5-20-RERE | 20 (40 μL) | 200 μL |
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| KRT6A-CXCR5-20-REOR | 20 (40 μL) | 200 μL |
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| KRT6A-CXCR5-20-REGO | 20 (40 μL) | 200 μL |
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| KRT6A-CXCR5-20-REGR | 20 (40 μL) | 200 μL |
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| KRT6A-CXCR5-20-REAQ | 20 (40 μL) | 200 μL |
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| KRT6A-CXCR5-20-ORRE | 20 (40 μL) | 200 μL |
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| KRT6A-CXCR5-20-OROR | 20 (40 μL) | 200 μL |
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| KRT6A-CXCR5-20-ORGO | 20 (40 μL) | 200 μL |
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| KRT6A-CXCR5-20-ORAQ | 20 (40 μL) | 200 μL |
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| KRT6A-CXCR5-20-GORE | 20 (40 μL) | 200 μL |
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| KRT6A-CXCR5-20-GOOR | 20 (40 μL) | 200 μL |
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| KRT6A-CXCR5-20-GOGO | 20 (40 μL) | 200 μL |
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| KRT6A-CXCR5-20-GOGR | 20 (40 μL) | 200 μL |
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| KRT6A-CXCR5-20-GOAQ | 20 (40 μL) | 200 μL |
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| KRT6A-CXCR5-20-GRRE | 20 (40 μL) | 200 μL |
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| KRT6A-CXCR5-20-GROR | 20 (40 μL) | 200 μL |
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| KRT6A-CXCR5-20-GRGO | 20 (40 μL) | 200 μL |
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| KRT6A-CXCR5-20-GRGR | 20 (40 μL) | 200 μL |
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| KRT6A-CXCR5-20-GRAQ | 20 (40 μL) | 200 μL |
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| KRT6A-CXCR5-20-AQRE | 20 (40 μL) | 200 μL |
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| KRT6A-CXCR5-20-AQOR | 20 (40 μL) | 200 μL |
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| KRT6A-CXCR5-20-AQGO | 20 (40 μL) | 200 μL |
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| KRT6A-CXCR5-20-AQGR | 20 (40 μL) | 200 μL |
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| KRT6A-CXCR5-20-AQAQ | 20 (40 μL) | 200 μL |
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CXCR5 Gene Summary
This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Gene Name: C-X-C Motif Chemokine Receptor 5
Chromosome: CHR11: 118754474 -118766980
Locus: 11q23.3
KRT6A Gene Summary
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. In addition, peptides from the C-terminal region of the protein have antimicrobial activity against bacterial pathogens. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Oct 2014]
Gene Name: Keratin 6A
Chromosome: CHR12: 52880957 -52887181
Locus: 12q13.13
Gene Diseases
The KRT6A CXCR5 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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