KRT5-TYK2 Fusion FISH Probe
The KRT5-TYK2 Fusion FISH Probe is used to confirm a fusion of the KRT5 and TYK2 genes. The fusion of the KRT5 and TYK2 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| KRT5-TYK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| KRT5-TYK2-20-RERE | 20 (40 μL) | 200 μL |
|
|
| KRT5-TYK2-20-REOR | 20 (40 μL) | 200 μL |
|
|
| KRT5-TYK2-20-REGO | 20 (40 μL) | 200 μL |
|
|
| KRT5-TYK2-20-REGR | 20 (40 μL) | 200 μL |
|
|
| KRT5-TYK2-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| KRT5-TYK2-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| KRT5-TYK2-20-OROR | 20 (40 μL) | 200 μL |
|
|
| KRT5-TYK2-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| KRT5-TYK2-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| KRT5-TYK2-20-GORE | 20 (40 μL) | 200 μL |
|
|
| KRT5-TYK2-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| KRT5-TYK2-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| KRT5-TYK2-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| KRT5-TYK2-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| KRT5-TYK2-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| KRT5-TYK2-20-GROR | 20 (40 μL) | 200 μL |
|
|
| KRT5-TYK2-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| KRT5-TYK2-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| KRT5-TYK2-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| KRT5-TYK2-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| KRT5-TYK2-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| KRT5-TYK2-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| KRT5-TYK2-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| KRT5-TYK2-20-AQAQ | 20 (40 μL) | 200 μL |
|
KRT5 Gene Summary
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Gene Name: Keratin 5
Chromosome: CHR12: 52908358 -52914243
Locus: 12q13.13
TYK2 Gene Summary
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
Gene Name: Tyrosine Kinase 2
Chromosome: CHR19: 10461203 -10491248
Locus: 19p13.2
Gene Diseases
The KRT5 TYK2 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|