KRT5-PLAT Fusion FISH Probe
The KRT5-PLAT Fusion FISH Probe is used to confirm a fusion of the KRT5 and PLAT genes. The fusion of the KRT5 and PLAT genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KRT5-PLAT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KRT5-PLAT-20-RERE | 20 (40 μL) | 200 μL |
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| KRT5-PLAT-20-REOR | 20 (40 μL) | 200 μL |
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| KRT5-PLAT-20-REGO | 20 (40 μL) | 200 μL |
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| KRT5-PLAT-20-REGR | 20 (40 μL) | 200 μL |
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| KRT5-PLAT-20-REAQ | 20 (40 μL) | 200 μL |
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| KRT5-PLAT-20-ORRE | 20 (40 μL) | 200 μL |
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| KRT5-PLAT-20-OROR | 20 (40 μL) | 200 μL |
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| KRT5-PLAT-20-ORGO | 20 (40 μL) | 200 μL |
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| KRT5-PLAT-20-ORAQ | 20 (40 μL) | 200 μL |
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| KRT5-PLAT-20-GORE | 20 (40 μL) | 200 μL |
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| KRT5-PLAT-20-GOOR | 20 (40 μL) | 200 μL |
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| KRT5-PLAT-20-GOGO | 20 (40 μL) | 200 μL |
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| KRT5-PLAT-20-GOGR | 20 (40 μL) | 200 μL |
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| KRT5-PLAT-20-GOAQ | 20 (40 μL) | 200 μL |
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| KRT5-PLAT-20-GRRE | 20 (40 μL) | 200 μL |
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| KRT5-PLAT-20-GROR | 20 (40 μL) | 200 μL |
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| KRT5-PLAT-20-GRGO | 20 (40 μL) | 200 μL |
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| KRT5-PLAT-20-GRGR | 20 (40 μL) | 200 μL |
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| KRT5-PLAT-20-GRAQ | 20 (40 μL) | 200 μL |
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| KRT5-PLAT-20-AQRE | 20 (40 μL) | 200 μL |
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| KRT5-PLAT-20-AQOR | 20 (40 μL) | 200 μL |
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| KRT5-PLAT-20-AQGO | 20 (40 μL) | 200 μL |
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| KRT5-PLAT-20-AQGR | 20 (40 μL) | 200 μL |
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| KRT5-PLAT-20-AQAQ | 20 (40 μL) | 200 μL |
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KRT5 Gene Summary
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Gene Name: Keratin 5
Chromosome: CHR12: 52908358 -52914243
Locus: 12q13.13
PLAT Gene Summary
This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Gene Name: Plasminogen Activator, Tissue Type
Chromosome: CHR8: 42032235 -42065194
Locus: 8p11.21
Gene Diseases
The KRT5 PLAT Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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