KRT5-HLA-DRA Fusion FISH Probe
The KRT5-HLA-DRA Fusion FISH Probe is used to confirm a fusion of the KRT5 and HLA-DRA genes. The fusion of the KRT5 and HLA-DRA genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KRT5-HLA-DRA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KRT5-HLA-DRA-20-RERE | 20 (40 μL) | 200 μL |
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| KRT5-HLA-DRA-20-REOR | 20 (40 μL) | 200 μL |
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| KRT5-HLA-DRA-20-REGO | 20 (40 μL) | 200 μL |
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| KRT5-HLA-DRA-20-REGR | 20 (40 μL) | 200 μL |
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| KRT5-HLA-DRA-20-REAQ | 20 (40 μL) | 200 μL |
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| KRT5-HLA-DRA-20-ORRE | 20 (40 μL) | 200 μL |
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| KRT5-HLA-DRA-20-OROR | 20 (40 μL) | 200 μL |
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| KRT5-HLA-DRA-20-ORGO | 20 (40 μL) | 200 μL |
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| KRT5-HLA-DRA-20-ORAQ | 20 (40 μL) | 200 μL |
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| KRT5-HLA-DRA-20-GORE | 20 (40 μL) | 200 μL |
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| KRT5-HLA-DRA-20-GOOR | 20 (40 μL) | 200 μL |
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| KRT5-HLA-DRA-20-GOGO | 20 (40 μL) | 200 μL |
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| KRT5-HLA-DRA-20-GOGR | 20 (40 μL) | 200 μL |
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| KRT5-HLA-DRA-20-GOAQ | 20 (40 μL) | 200 μL |
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| KRT5-HLA-DRA-20-GRRE | 20 (40 μL) | 200 μL |
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| KRT5-HLA-DRA-20-GROR | 20 (40 μL) | 200 μL |
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| KRT5-HLA-DRA-20-GRGO | 20 (40 μL) | 200 μL |
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| KRT5-HLA-DRA-20-GRGR | 20 (40 μL) | 200 μL |
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| KRT5-HLA-DRA-20-GRAQ | 20 (40 μL) | 200 μL |
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| KRT5-HLA-DRA-20-AQRE | 20 (40 μL) | 200 μL |
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| KRT5-HLA-DRA-20-AQOR | 20 (40 μL) | 200 μL |
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| KRT5-HLA-DRA-20-AQGO | 20 (40 μL) | 200 μL |
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| KRT5-HLA-DRA-20-AQGR | 20 (40 μL) | 200 μL |
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| KRT5-HLA-DRA-20-AQAQ | 20 (40 μL) | 200 μL |
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HLA-DRA Gene Summary
HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Jul 2008]
Gene Name: Major Histocompatibility Complex, Class II, DR Alpha
Chromosome: CHR6_mann_hap4: 3749678 -3754894
Locus: 6p21.32
KRT5 Gene Summary
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Gene Name: Keratin 5
Chromosome: CHR12: 52908358 -52914243
Locus: 12q13.13
Gene Diseases
The KRT5 HLA-DRA Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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