KRT5-FOS Fusion FISH Probe
The KRT5-FOS Fusion FISH Probe is used to confirm a fusion of the KRT5 and FOS genes. The fusion of the KRT5 and FOS genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KRT5-FOS-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KRT5-FOS-20-RERE | 20 (40 μL) | 200 μL |
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| KRT5-FOS-20-REOR | 20 (40 μL) | 200 μL |
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| KRT5-FOS-20-REGO | 20 (40 μL) | 200 μL |
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| KRT5-FOS-20-REGR | 20 (40 μL) | 200 μL |
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| KRT5-FOS-20-REAQ | 20 (40 μL) | 200 μL |
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| KRT5-FOS-20-ORRE | 20 (40 μL) | 200 μL |
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| KRT5-FOS-20-OROR | 20 (40 μL) | 200 μL |
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| KRT5-FOS-20-ORGO | 20 (40 μL) | 200 μL |
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| KRT5-FOS-20-ORAQ | 20 (40 μL) | 200 μL |
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| KRT5-FOS-20-GORE | 20 (40 μL) | 200 μL |
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| KRT5-FOS-20-GOOR | 20 (40 μL) | 200 μL |
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| KRT5-FOS-20-GOGO | 20 (40 μL) | 200 μL |
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| KRT5-FOS-20-GOGR | 20 (40 μL) | 200 μL |
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| KRT5-FOS-20-GOAQ | 20 (40 μL) | 200 μL |
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| KRT5-FOS-20-GRRE | 20 (40 μL) | 200 μL |
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| KRT5-FOS-20-GROR | 20 (40 μL) | 200 μL |
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| KRT5-FOS-20-GRGO | 20 (40 μL) | 200 μL |
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| KRT5-FOS-20-GRGR | 20 (40 μL) | 200 μL |
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| KRT5-FOS-20-GRAQ | 20 (40 μL) | 200 μL |
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| KRT5-FOS-20-AQRE | 20 (40 μL) | 200 μL |
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| KRT5-FOS-20-AQOR | 20 (40 μL) | 200 μL |
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| KRT5-FOS-20-AQGO | 20 (40 μL) | 200 μL |
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| KRT5-FOS-20-AQGR | 20 (40 μL) | 200 μL |
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| KRT5-FOS-20-AQAQ | 20 (40 μL) | 200 μL |
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FOS Gene Summary
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]
Gene Name: Fos Proto-oncogene, AP-1 Transcription Factor Subunit
Chromosome: CHR14: 75745480 -75748937
Locus: 14q24.3
KRT5 Gene Summary
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Gene Name: Keratin 5
Chromosome: CHR12: 52908358 -52914243
Locus: 12q13.13
Gene Diseases
The KRT5 FOS Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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