KRT19-CLDN7 Fusion FISH Probe
The KRT19-CLDN7 Fusion FISH Probe is used to confirm a fusion of the KRT19 and CLDN7 genes. The fusion of the KRT19 and CLDN7 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KRT19-CLDN7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KRT19-CLDN7-20-RERE | 20 (40 μL) | 200 μL |
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| KRT19-CLDN7-20-REOR | 20 (40 μL) | 200 μL |
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| KRT19-CLDN7-20-REGO | 20 (40 μL) | 200 μL |
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| KRT19-CLDN7-20-REGR | 20 (40 μL) | 200 μL |
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| KRT19-CLDN7-20-REAQ | 20 (40 μL) | 200 μL |
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| KRT19-CLDN7-20-ORRE | 20 (40 μL) | 200 μL |
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| KRT19-CLDN7-20-OROR | 20 (40 μL) | 200 μL |
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| KRT19-CLDN7-20-ORGO | 20 (40 μL) | 200 μL |
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| KRT19-CLDN7-20-ORAQ | 20 (40 μL) | 200 μL |
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| KRT19-CLDN7-20-GORE | 20 (40 μL) | 200 μL |
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| KRT19-CLDN7-20-GOOR | 20 (40 μL) | 200 μL |
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| KRT19-CLDN7-20-GOGO | 20 (40 μL) | 200 μL |
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| KRT19-CLDN7-20-GOGR | 20 (40 μL) | 200 μL |
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| KRT19-CLDN7-20-GOAQ | 20 (40 μL) | 200 μL |
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| KRT19-CLDN7-20-GRRE | 20 (40 μL) | 200 μL |
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| KRT19-CLDN7-20-GROR | 20 (40 μL) | 200 μL |
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| KRT19-CLDN7-20-GRGO | 20 (40 μL) | 200 μL |
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| KRT19-CLDN7-20-GRGR | 20 (40 μL) | 200 μL |
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| KRT19-CLDN7-20-GRAQ | 20 (40 μL) | 200 μL |
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| KRT19-CLDN7-20-AQRE | 20 (40 μL) | 200 μL |
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| KRT19-CLDN7-20-AQOR | 20 (40 μL) | 200 μL |
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| KRT19-CLDN7-20-AQGO | 20 (40 μL) | 200 μL |
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| KRT19-CLDN7-20-AQGR | 20 (40 μL) | 200 μL |
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| KRT19-CLDN7-20-AQAQ | 20 (40 μL) | 200 μL |
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CLDN7 Gene Summary
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010]
Gene Name: Claudin 7
Chromosome: CHR17: 7163221 -7166512
Locus: 17p13.1
KRT19 Gene Summary
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]
Gene Name: Keratin 19
Chromosome: CHR17: 39679868 -39684641
Locus: 17q21.2
Gene Diseases
The KRT19 CLDN7 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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