KRT19-C7 Fusion FISH Probe
The KRT19-C7 Fusion FISH Probe is used to confirm a fusion of the KRT19 and C7 genes. The fusion of the KRT19 and C7 genes has been associated with Mesothelioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KRT19-C7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KRT19-C7-20-RERE | 20 (40 μL) | 200 μL |
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| KRT19-C7-20-REOR | 20 (40 μL) | 200 μL |
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| KRT19-C7-20-REGO | 20 (40 μL) | 200 μL |
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| KRT19-C7-20-REGR | 20 (40 μL) | 200 μL |
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| KRT19-C7-20-REAQ | 20 (40 μL) | 200 μL |
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| KRT19-C7-20-ORRE | 20 (40 μL) | 200 μL |
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| KRT19-C7-20-OROR | 20 (40 μL) | 200 μL |
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| KRT19-C7-20-ORGO | 20 (40 μL) | 200 μL |
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| KRT19-C7-20-ORAQ | 20 (40 μL) | 200 μL |
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| KRT19-C7-20-GORE | 20 (40 μL) | 200 μL |
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| KRT19-C7-20-GOOR | 20 (40 μL) | 200 μL |
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| KRT19-C7-20-GOGO | 20 (40 μL) | 200 μL |
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| KRT19-C7-20-GOGR | 20 (40 μL) | 200 μL |
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| KRT19-C7-20-GOAQ | 20 (40 μL) | 200 μL |
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| KRT19-C7-20-GRRE | 20 (40 μL) | 200 μL |
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| KRT19-C7-20-GROR | 20 (40 μL) | 200 μL |
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| KRT19-C7-20-GRGO | 20 (40 μL) | 200 μL |
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| KRT19-C7-20-GRGR | 20 (40 μL) | 200 μL |
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| KRT19-C7-20-GRAQ | 20 (40 μL) | 200 μL |
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| KRT19-C7-20-AQRE | 20 (40 μL) | 200 μL |
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| KRT19-C7-20-AQOR | 20 (40 μL) | 200 μL |
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| KRT19-C7-20-AQGO | 20 (40 μL) | 200 μL |
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| KRT19-C7-20-AQGR | 20 (40 μL) | 200 μL |
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| KRT19-C7-20-AQAQ | 20 (40 μL) | 200 μL |
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C7 Gene Summary
This gene encodes a serum glycoprotein that forms a membrane attack complex together with complement components C5b, C6, C8, and C9 as part of the terminal complement pathway of the innate immune system. The protein encoded by this gene contains a cholesterol-dependent cytolysin/membrane attack complex/perforin-like (CDC/MACPF) domain and belongs to a large family of structurally related molecules that form pores involved in host immunity and bacterial pathogenesis. This protein initiates membrane attack complex formation by binding the C5b-C6 subcomplex and inserts into the phospholipid bilayer, serving as a membrane anchor. Mutations in this gene are associated with a rare disorder called C7 deficiency. [provided by RefSeq, Nov 2016]
Gene Name: Complement C7
Chromosome: CHR5: 40909598 -40983042
Locus: 5p13.1
KRT19 Gene Summary
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]
Gene Name: Keratin 19
Chromosome: CHR17: 39679868 -39684641
Locus: 17q21.2
Gene Diseases
The KRT19 C7 Fusion has been associated with the following diseases:
| Disease Name |
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| Mesothelioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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