KRT14-TYK2 Fusion FISH Probe
The KRT14-TYK2 Fusion FISH Probe is used to confirm a fusion of the KRT14 and TYK2 genes. The fusion of the KRT14 and TYK2 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KRT14-TYK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KRT14-TYK2-20-RERE | 20 (40 μL) | 200 μL |
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| KRT14-TYK2-20-REOR | 20 (40 μL) | 200 μL |
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| KRT14-TYK2-20-REGO | 20 (40 μL) | 200 μL |
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| KRT14-TYK2-20-REGR | 20 (40 μL) | 200 μL |
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| KRT14-TYK2-20-REAQ | 20 (40 μL) | 200 μL |
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| KRT14-TYK2-20-ORRE | 20 (40 μL) | 200 μL |
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| KRT14-TYK2-20-OROR | 20 (40 μL) | 200 μL |
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| KRT14-TYK2-20-ORGO | 20 (40 μL) | 200 μL |
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| KRT14-TYK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| KRT14-TYK2-20-GORE | 20 (40 μL) | 200 μL |
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| KRT14-TYK2-20-GOOR | 20 (40 μL) | 200 μL |
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| KRT14-TYK2-20-GOGO | 20 (40 μL) | 200 μL |
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| KRT14-TYK2-20-GOGR | 20 (40 μL) | 200 μL |
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| KRT14-TYK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| KRT14-TYK2-20-GRRE | 20 (40 μL) | 200 μL |
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| KRT14-TYK2-20-GROR | 20 (40 μL) | 200 μL |
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| KRT14-TYK2-20-GRGO | 20 (40 μL) | 200 μL |
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| KRT14-TYK2-20-GRGR | 20 (40 μL) | 200 μL |
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| KRT14-TYK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| KRT14-TYK2-20-AQRE | 20 (40 μL) | 200 μL |
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| KRT14-TYK2-20-AQOR | 20 (40 μL) | 200 μL |
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| KRT14-TYK2-20-AQGO | 20 (40 μL) | 200 μL |
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| KRT14-TYK2-20-AQGR | 20 (40 μL) | 200 μL |
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| KRT14-TYK2-20-AQAQ | 20 (40 μL) | 200 μL |
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KRT14 Gene Summary
This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. [provided by RefSeq, Jul 2008]
Gene Name: Keratin 14
Chromosome: CHR17: 39738530 -39743147
Locus: 17q21.2
TYK2 Gene Summary
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
Gene Name: Tyrosine Kinase 2
Chromosome: CHR19: 10461203 -10491248
Locus: 19p13.2
Gene Diseases
The KRT14 TYK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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