KRT14-SUPT16H Fusion FISH Probe
The KRT14-SUPT16H Fusion FISH Probe is used to confirm a fusion of the KRT14 and SUPT16H genes. The fusion of the KRT14 and SUPT16H genes has been associated with Bladder Urothelial Carcinoma, and Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KRT14-SUPT16H-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KRT14-SUPT16H-20-RERE | 20 (40 μL) | 200 μL |
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| KRT14-SUPT16H-20-REOR | 20 (40 μL) | 200 μL |
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| KRT14-SUPT16H-20-REGO | 20 (40 μL) | 200 μL |
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| KRT14-SUPT16H-20-REGR | 20 (40 μL) | 200 μL |
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| KRT14-SUPT16H-20-REAQ | 20 (40 μL) | 200 μL |
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| KRT14-SUPT16H-20-ORRE | 20 (40 μL) | 200 μL |
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| KRT14-SUPT16H-20-OROR | 20 (40 μL) | 200 μL |
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| KRT14-SUPT16H-20-ORGO | 20 (40 μL) | 200 μL |
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| KRT14-SUPT16H-20-ORAQ | 20 (40 μL) | 200 μL |
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| KRT14-SUPT16H-20-GORE | 20 (40 μL) | 200 μL |
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| KRT14-SUPT16H-20-GOOR | 20 (40 μL) | 200 μL |
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| KRT14-SUPT16H-20-GOGO | 20 (40 μL) | 200 μL |
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| KRT14-SUPT16H-20-GOGR | 20 (40 μL) | 200 μL |
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| KRT14-SUPT16H-20-GOAQ | 20 (40 μL) | 200 μL |
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| KRT14-SUPT16H-20-GRRE | 20 (40 μL) | 200 μL |
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| KRT14-SUPT16H-20-GROR | 20 (40 μL) | 200 μL |
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| KRT14-SUPT16H-20-GRGO | 20 (40 μL) | 200 μL |
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| KRT14-SUPT16H-20-GRGR | 20 (40 μL) | 200 μL |
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| KRT14-SUPT16H-20-GRAQ | 20 (40 μL) | 200 μL |
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| KRT14-SUPT16H-20-AQRE | 20 (40 μL) | 200 μL |
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| KRT14-SUPT16H-20-AQOR | 20 (40 μL) | 200 μL |
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| KRT14-SUPT16H-20-AQGO | 20 (40 μL) | 200 μL |
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| KRT14-SUPT16H-20-AQGR | 20 (40 μL) | 200 μL |
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| KRT14-SUPT16H-20-AQAQ | 20 (40 μL) | 200 μL |
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KRT14 Gene Summary
This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. [provided by RefSeq, Jul 2008]
Gene Name: Keratin 14
Chromosome: CHR17: 39738530 -39743147
Locus: 17q21.2
SUPT16H Gene Summary
Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]
Gene Name: SPT16 Homolog, Facilitates Chromatin Remodeling Subunit
Chromosome: CHR14: 21819630 -21852425
Locus: 14q11.2
Gene Diseases
The KRT14 SUPT16H Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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