KRT14-CYP2C18 Fusion FISH Probe
The KRT14-CYP2C18 Fusion FISH Probe is used to confirm a fusion of the KRT14 and CYP2C18 genes. The fusion of the KRT14 and CYP2C18 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KRT14-CYP2C18-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KRT14-CYP2C18-20-RERE | 20 (40 μL) | 200 μL |
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| KRT14-CYP2C18-20-REOR | 20 (40 μL) | 200 μL |
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| KRT14-CYP2C18-20-REGO | 20 (40 μL) | 200 μL |
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| KRT14-CYP2C18-20-REGR | 20 (40 μL) | 200 μL |
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| KRT14-CYP2C18-20-REAQ | 20 (40 μL) | 200 μL |
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| KRT14-CYP2C18-20-ORRE | 20 (40 μL) | 200 μL |
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| KRT14-CYP2C18-20-OROR | 20 (40 μL) | 200 μL |
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| KRT14-CYP2C18-20-ORGO | 20 (40 μL) | 200 μL |
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| KRT14-CYP2C18-20-ORAQ | 20 (40 μL) | 200 μL |
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| KRT14-CYP2C18-20-GORE | 20 (40 μL) | 200 μL |
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| KRT14-CYP2C18-20-GOOR | 20 (40 μL) | 200 μL |
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| KRT14-CYP2C18-20-GOGO | 20 (40 μL) | 200 μL |
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| KRT14-CYP2C18-20-GOGR | 20 (40 μL) | 200 μL |
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| KRT14-CYP2C18-20-GOAQ | 20 (40 μL) | 200 μL |
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| KRT14-CYP2C18-20-GRRE | 20 (40 μL) | 200 μL |
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| KRT14-CYP2C18-20-GROR | 20 (40 μL) | 200 μL |
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| KRT14-CYP2C18-20-GRGO | 20 (40 μL) | 200 μL |
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| KRT14-CYP2C18-20-GRGR | 20 (40 μL) | 200 μL |
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| KRT14-CYP2C18-20-GRAQ | 20 (40 μL) | 200 μL |
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| KRT14-CYP2C18-20-AQRE | 20 (40 μL) | 200 μL |
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| KRT14-CYP2C18-20-AQOR | 20 (40 μL) | 200 μL |
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| KRT14-CYP2C18-20-AQGO | 20 (40 μL) | 200 μL |
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| KRT14-CYP2C18-20-AQGR | 20 (40 μL) | 200 μL |
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| KRT14-CYP2C18-20-AQAQ | 20 (40 μL) | 200 μL |
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CYP2C18 Gene Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Cytochrome P450 Family 2 Subfamily C Member 18
Chromosome: CHR10: 96443250 -96495947
Locus: 10q23.33
KRT14 Gene Summary
This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. [provided by RefSeq, Jul 2008]
Gene Name: Keratin 14
Chromosome: CHR17: 39738530 -39743147
Locus: 17q21.2
Gene Diseases
The KRT14 CYP2C18 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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