KRT13-SUPT16H Fusion FISH Probe
The KRT13-SUPT16H Fusion FISH Probe is used to confirm a fusion of the KRT13 and SUPT16H genes. The fusion of the KRT13 and SUPT16H genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KRT13-SUPT16H-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KRT13-SUPT16H-20-RERE | 20 (40 μL) | 200 μL |
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| KRT13-SUPT16H-20-REOR | 20 (40 μL) | 200 μL |
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| KRT13-SUPT16H-20-REGO | 20 (40 μL) | 200 μL |
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| KRT13-SUPT16H-20-REGR | 20 (40 μL) | 200 μL |
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| KRT13-SUPT16H-20-REAQ | 20 (40 μL) | 200 μL |
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| KRT13-SUPT16H-20-ORRE | 20 (40 μL) | 200 μL |
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| KRT13-SUPT16H-20-OROR | 20 (40 μL) | 200 μL |
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| KRT13-SUPT16H-20-ORGO | 20 (40 μL) | 200 μL |
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| KRT13-SUPT16H-20-ORAQ | 20 (40 μL) | 200 μL |
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| KRT13-SUPT16H-20-GORE | 20 (40 μL) | 200 μL |
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| KRT13-SUPT16H-20-GOOR | 20 (40 μL) | 200 μL |
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| KRT13-SUPT16H-20-GOGO | 20 (40 μL) | 200 μL |
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| KRT13-SUPT16H-20-GOGR | 20 (40 μL) | 200 μL |
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| KRT13-SUPT16H-20-GOAQ | 20 (40 μL) | 200 μL |
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| KRT13-SUPT16H-20-GRRE | 20 (40 μL) | 200 μL |
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| KRT13-SUPT16H-20-GROR | 20 (40 μL) | 200 μL |
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| KRT13-SUPT16H-20-GRGO | 20 (40 μL) | 200 μL |
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| KRT13-SUPT16H-20-GRGR | 20 (40 μL) | 200 μL |
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| KRT13-SUPT16H-20-GRAQ | 20 (40 μL) | 200 μL |
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| KRT13-SUPT16H-20-AQRE | 20 (40 μL) | 200 μL |
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| KRT13-SUPT16H-20-AQOR | 20 (40 μL) | 200 μL |
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| KRT13-SUPT16H-20-AQGO | 20 (40 μL) | 200 μL |
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| KRT13-SUPT16H-20-AQGR | 20 (40 μL) | 200 μL |
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| KRT13-SUPT16H-20-AQAQ | 20 (40 μL) | 200 μL |
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KRT13 Gene Summary
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. [provided by RefSeq, Jul 2008]
Gene Name: Keratin 13
Chromosome: CHR17: 39657232 -39661865
Locus: 17q21.2
SUPT16H Gene Summary
Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]
Gene Name: SPT16 Homolog, Facilitates Chromatin Remodeling Subunit
Chromosome: CHR14: 21819630 -21852425
Locus: 14q11.2
Gene Diseases
The KRT13 SUPT16H Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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