KRT13-STAT6 Fusion FISH Probe
The KRT13-STAT6 Fusion FISH Probe is used to confirm a fusion of the KRT13 and STAT6 genes. The fusion of the KRT13 and STAT6 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KRT13-STAT6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KRT13-STAT6-20-RERE | 20 (40 μL) | 200 μL |
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| KRT13-STAT6-20-REOR | 20 (40 μL) | 200 μL |
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| KRT13-STAT6-20-REGO | 20 (40 μL) | 200 μL |
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| KRT13-STAT6-20-REGR | 20 (40 μL) | 200 μL |
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| KRT13-STAT6-20-REAQ | 20 (40 μL) | 200 μL |
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| KRT13-STAT6-20-ORRE | 20 (40 μL) | 200 μL |
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| KRT13-STAT6-20-OROR | 20 (40 μL) | 200 μL |
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| KRT13-STAT6-20-ORGO | 20 (40 μL) | 200 μL |
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| KRT13-STAT6-20-ORAQ | 20 (40 μL) | 200 μL |
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| KRT13-STAT6-20-GORE | 20 (40 μL) | 200 μL |
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| KRT13-STAT6-20-GOOR | 20 (40 μL) | 200 μL |
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| KRT13-STAT6-20-GOGO | 20 (40 μL) | 200 μL |
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| KRT13-STAT6-20-GOGR | 20 (40 μL) | 200 μL |
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| KRT13-STAT6-20-GOAQ | 20 (40 μL) | 200 μL |
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| KRT13-STAT6-20-GRRE | 20 (40 μL) | 200 μL |
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| KRT13-STAT6-20-GROR | 20 (40 μL) | 200 μL |
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| KRT13-STAT6-20-GRGO | 20 (40 μL) | 200 μL |
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| KRT13-STAT6-20-GRGR | 20 (40 μL) | 200 μL |
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| KRT13-STAT6-20-GRAQ | 20 (40 μL) | 200 μL |
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| KRT13-STAT6-20-AQRE | 20 (40 μL) | 200 μL |
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| KRT13-STAT6-20-AQOR | 20 (40 μL) | 200 μL |
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| KRT13-STAT6-20-AQGO | 20 (40 μL) | 200 μL |
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| KRT13-STAT6-20-AQGR | 20 (40 μL) | 200 μL |
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| KRT13-STAT6-20-AQAQ | 20 (40 μL) | 200 μL |
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KRT13 Gene Summary
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. [provided by RefSeq, Jul 2008]
Gene Name: Keratin 13
Chromosome: CHR17: 39657232 -39661865
Locus: 17q21.2
STAT6 Gene Summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Name: Signal Transducer And Activator Of Transcription 6
Chromosome: CHR12: 57489186 -57505196
Locus: 12q13.3
Gene Diseases
The KRT13 STAT6 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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