KRT13-PLAT Fusion FISH Probe
The KRT13-PLAT Fusion FISH Probe is used to confirm a fusion of the KRT13 and PLAT genes. The fusion of the KRT13 and PLAT genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KRT13-PLAT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KRT13-PLAT-20-RERE | 20 (40 μL) | 200 μL |
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| KRT13-PLAT-20-REOR | 20 (40 μL) | 200 μL |
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| KRT13-PLAT-20-REGO | 20 (40 μL) | 200 μL |
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| KRT13-PLAT-20-REGR | 20 (40 μL) | 200 μL |
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| KRT13-PLAT-20-REAQ | 20 (40 μL) | 200 μL |
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| KRT13-PLAT-20-ORRE | 20 (40 μL) | 200 μL |
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| KRT13-PLAT-20-OROR | 20 (40 μL) | 200 μL |
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| KRT13-PLAT-20-ORGO | 20 (40 μL) | 200 μL |
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| KRT13-PLAT-20-ORAQ | 20 (40 μL) | 200 μL |
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| KRT13-PLAT-20-GORE | 20 (40 μL) | 200 μL |
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| KRT13-PLAT-20-GOOR | 20 (40 μL) | 200 μL |
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| KRT13-PLAT-20-GOGO | 20 (40 μL) | 200 μL |
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| KRT13-PLAT-20-GOGR | 20 (40 μL) | 200 μL |
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| KRT13-PLAT-20-GOAQ | 20 (40 μL) | 200 μL |
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| KRT13-PLAT-20-GRRE | 20 (40 μL) | 200 μL |
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| KRT13-PLAT-20-GROR | 20 (40 μL) | 200 μL |
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| KRT13-PLAT-20-GRGO | 20 (40 μL) | 200 μL |
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| KRT13-PLAT-20-GRGR | 20 (40 μL) | 200 μL |
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| KRT13-PLAT-20-GRAQ | 20 (40 μL) | 200 μL |
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| KRT13-PLAT-20-AQRE | 20 (40 μL) | 200 μL |
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| KRT13-PLAT-20-AQOR | 20 (40 μL) | 200 μL |
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| KRT13-PLAT-20-AQGO | 20 (40 μL) | 200 μL |
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| KRT13-PLAT-20-AQGR | 20 (40 μL) | 200 μL |
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| KRT13-PLAT-20-AQAQ | 20 (40 μL) | 200 μL |
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KRT13 Gene Summary
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. [provided by RefSeq, Jul 2008]
Gene Name: Keratin 13
Chromosome: CHR17: 39657232 -39661865
Locus: 17q21.2
PLAT Gene Summary
This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Gene Name: Plasminogen Activator, Tissue Type
Chromosome: CHR8: 42032235 -42065194
Locus: 8p11.21
Gene Diseases
The KRT13 PLAT Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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