KRT13-FAR1 Fusion FISH Probe
The KRT13-FAR1 Fusion FISH Probe is used to confirm a fusion of the KRT13 and FAR1 genes. The fusion of the KRT13 and FAR1 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KRT13-FAR1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KRT13-FAR1-20-RERE | 20 (40 μL) | 200 μL |
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| KRT13-FAR1-20-REOR | 20 (40 μL) | 200 μL |
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| KRT13-FAR1-20-REGO | 20 (40 μL) | 200 μL |
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| KRT13-FAR1-20-REGR | 20 (40 μL) | 200 μL |
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| KRT13-FAR1-20-REAQ | 20 (40 μL) | 200 μL |
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| KRT13-FAR1-20-ORRE | 20 (40 μL) | 200 μL |
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| KRT13-FAR1-20-OROR | 20 (40 μL) | 200 μL |
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| KRT13-FAR1-20-ORGO | 20 (40 μL) | 200 μL |
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| KRT13-FAR1-20-ORAQ | 20 (40 μL) | 200 μL |
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| KRT13-FAR1-20-GORE | 20 (40 μL) | 200 μL |
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| KRT13-FAR1-20-GOOR | 20 (40 μL) | 200 μL |
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| KRT13-FAR1-20-GOGO | 20 (40 μL) | 200 μL |
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| KRT13-FAR1-20-GOGR | 20 (40 μL) | 200 μL |
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| KRT13-FAR1-20-GOAQ | 20 (40 μL) | 200 μL |
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| KRT13-FAR1-20-GRRE | 20 (40 μL) | 200 μL |
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| KRT13-FAR1-20-GROR | 20 (40 μL) | 200 μL |
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| KRT13-FAR1-20-GRGO | 20 (40 μL) | 200 μL |
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| KRT13-FAR1-20-GRGR | 20 (40 μL) | 200 μL |
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| KRT13-FAR1-20-GRAQ | 20 (40 μL) | 200 μL |
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| KRT13-FAR1-20-AQRE | 20 (40 μL) | 200 μL |
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| KRT13-FAR1-20-AQOR | 20 (40 μL) | 200 μL |
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| KRT13-FAR1-20-AQGO | 20 (40 μL) | 200 μL |
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| KRT13-FAR1-20-AQGR | 20 (40 μL) | 200 μL |
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| KRT13-FAR1-20-AQAQ | 20 (40 μL) | 200 μL |
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KRT13 Gene Summary
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. [provided by RefSeq, Jul 2008]
Gene Name: Keratin 13
Chromosome: CHR17: 39657232 -39661865
Locus: 17q21.2
FAR1 Gene Summary
The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome, while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity (PMID: 25439727). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jan 2015]
Gene Name: Fatty Acyl-CoA Reductase 1
Chromosome: CHR11: 13690205 -13753893
Locus: 11p15.3
Gene Diseases
The KRT13 FAR1 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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