KRT13-DDX21 Fusion FISH Probe
The KRT13-DDX21 Fusion FISH Probe is used to confirm a fusion of the KRT13 and DDX21 genes. The fusion of the KRT13 and DDX21 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KRT13-DDX21-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KRT13-DDX21-20-RERE | 20 (40 μL) | 200 μL |
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| KRT13-DDX21-20-REOR | 20 (40 μL) | 200 μL |
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| KRT13-DDX21-20-REGO | 20 (40 μL) | 200 μL |
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| KRT13-DDX21-20-REGR | 20 (40 μL) | 200 μL |
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| KRT13-DDX21-20-REAQ | 20 (40 μL) | 200 μL |
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| KRT13-DDX21-20-ORRE | 20 (40 μL) | 200 μL |
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| KRT13-DDX21-20-OROR | 20 (40 μL) | 200 μL |
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| KRT13-DDX21-20-ORGO | 20 (40 μL) | 200 μL |
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| KRT13-DDX21-20-ORAQ | 20 (40 μL) | 200 μL |
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| KRT13-DDX21-20-GORE | 20 (40 μL) | 200 μL |
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| KRT13-DDX21-20-GOOR | 20 (40 μL) | 200 μL |
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| KRT13-DDX21-20-GOGO | 20 (40 μL) | 200 μL |
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| KRT13-DDX21-20-GOGR | 20 (40 μL) | 200 μL |
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| KRT13-DDX21-20-GOAQ | 20 (40 μL) | 200 μL |
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| KRT13-DDX21-20-GRRE | 20 (40 μL) | 200 μL |
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| KRT13-DDX21-20-GROR | 20 (40 μL) | 200 μL |
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| KRT13-DDX21-20-GRGO | 20 (40 μL) | 200 μL |
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| KRT13-DDX21-20-GRGR | 20 (40 μL) | 200 μL |
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| KRT13-DDX21-20-GRAQ | 20 (40 μL) | 200 μL |
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| KRT13-DDX21-20-AQRE | 20 (40 μL) | 200 μL |
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| KRT13-DDX21-20-AQOR | 20 (40 μL) | 200 μL |
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| KRT13-DDX21-20-AQGO | 20 (40 μL) | 200 μL |
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| KRT13-DDX21-20-AQGR | 20 (40 μL) | 200 μL |
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| KRT13-DDX21-20-AQAQ | 20 (40 μL) | 200 μL |
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KRT13 Gene Summary
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. [provided by RefSeq, Jul 2008]
Gene Name: Keratin 13
Chromosome: CHR17: 39657232 -39661865
Locus: 17q21.2
DDX21 Gene Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. [provided by RefSeq, Jul 2008]
Gene Name: DExD-box Helicase 21
Chromosome: CHR10: 70715891 -70744279
Locus: 10q22.1
Gene Diseases
The KRT13 DDX21 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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