KRT13-AP1G2 Fusion FISH Probe
The KRT13-AP1G2 Fusion FISH Probe is used to confirm a fusion of the KRT13 and AP1G2 genes. The fusion of the KRT13 and AP1G2 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KRT13-AP1G2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KRT13-AP1G2-20-RERE | 20 (40 μL) | 200 μL |
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| KRT13-AP1G2-20-REOR | 20 (40 μL) | 200 μL |
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| KRT13-AP1G2-20-REGO | 20 (40 μL) | 200 μL |
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| KRT13-AP1G2-20-REGR | 20 (40 μL) | 200 μL |
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| KRT13-AP1G2-20-REAQ | 20 (40 μL) | 200 μL |
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| KRT13-AP1G2-20-ORRE | 20 (40 μL) | 200 μL |
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| KRT13-AP1G2-20-OROR | 20 (40 μL) | 200 μL |
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| KRT13-AP1G2-20-ORGO | 20 (40 μL) | 200 μL |
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| KRT13-AP1G2-20-ORAQ | 20 (40 μL) | 200 μL |
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| KRT13-AP1G2-20-GORE | 20 (40 μL) | 200 μL |
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| KRT13-AP1G2-20-GOOR | 20 (40 μL) | 200 μL |
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| KRT13-AP1G2-20-GOGO | 20 (40 μL) | 200 μL |
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| KRT13-AP1G2-20-GOGR | 20 (40 μL) | 200 μL |
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| KRT13-AP1G2-20-GOAQ | 20 (40 μL) | 200 μL |
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| KRT13-AP1G2-20-GRRE | 20 (40 μL) | 200 μL |
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| KRT13-AP1G2-20-GROR | 20 (40 μL) | 200 μL |
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| KRT13-AP1G2-20-GRGO | 20 (40 μL) | 200 μL |
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| KRT13-AP1G2-20-GRGR | 20 (40 μL) | 200 μL |
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| KRT13-AP1G2-20-GRAQ | 20 (40 μL) | 200 μL |
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| KRT13-AP1G2-20-AQRE | 20 (40 μL) | 200 μL |
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| KRT13-AP1G2-20-AQOR | 20 (40 μL) | 200 μL |
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| KRT13-AP1G2-20-AQGO | 20 (40 μL) | 200 μL |
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| KRT13-AP1G2-20-AQGR | 20 (40 μL) | 200 μL |
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| KRT13-AP1G2-20-AQAQ | 20 (40 μL) | 200 μL |
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KRT13 Gene Summary
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. [provided by RefSeq, Jul 2008]
Gene Name: Keratin 13
Chromosome: CHR17: 39657232 -39661865
Locus: 17q21.2
AP1G2 Gene Summary
Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. [provided by RefSeq, Aug 2017]
Gene Name: Adaptor Related Protein Complex 1 Gamma 2 Subunit
Chromosome: CHR14: 24028776 -24037279
Locus: 14q11.2
Gene Diseases
The KRT13 AP1G2 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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