KRIT1-GNGT1 Fusion FISH Probe
The KRIT1-GNGT1 Fusion FISH Probe is used to confirm a fusion of the KRIT1 and GNGT1 genes. The fusion of the KRIT1 and GNGT1 genes has been associated with Glioblastoma Multiforme. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| KRIT1-GNGT1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| KRIT1-GNGT1-20-RERE | 20 (40 μL) | 200 μL |
|
|
| KRIT1-GNGT1-20-REOR | 20 (40 μL) | 200 μL |
|
|
| KRIT1-GNGT1-20-REGO | 20 (40 μL) | 200 μL |
|
|
| KRIT1-GNGT1-20-REGR | 20 (40 μL) | 200 μL |
|
|
| KRIT1-GNGT1-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| KRIT1-GNGT1-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| KRIT1-GNGT1-20-OROR | 20 (40 μL) | 200 μL |
|
|
| KRIT1-GNGT1-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| KRIT1-GNGT1-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| KRIT1-GNGT1-20-GORE | 20 (40 μL) | 200 μL |
|
|
| KRIT1-GNGT1-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| KRIT1-GNGT1-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| KRIT1-GNGT1-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| KRIT1-GNGT1-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| KRIT1-GNGT1-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| KRIT1-GNGT1-20-GROR | 20 (40 μL) | 200 μL |
|
|
| KRIT1-GNGT1-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| KRIT1-GNGT1-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| KRIT1-GNGT1-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| KRIT1-GNGT1-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| KRIT1-GNGT1-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| KRIT1-GNGT1-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| KRIT1-GNGT1-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| KRIT1-GNGT1-20-AQAQ | 20 (40 μL) | 200 μL |
|
KRIT1 Gene Summary
This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Name: KRIT1, Ankyrin Repeat Containing
Chromosome: CHR7: 91828282 -91875414
Locus: 7q21.2
GNGT1 Gene Summary
This gene encodes the gamma subunit of transducin, a guanine nucleotide-binding protein (G protein) that is found in rod outer segments. Transducin, also known as GMPase, mediates the activation of a cyclic GTP-specific (guanosine monophosphate) phosphodiesterase by rhodopsin. [provided by RefSeq, Jul 2016]
Gene Name: G Protein Subunit Gamma Transducin 1
Chromosome: CHR7: 93535819 -93540485
Locus: 7q21.3
Gene Diseases
The KRIT1 GNGT1 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Glioblastoma Multiforme |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|