KPNB1-SKAP1 Fusion FISH Probe
The KPNB1-SKAP1 Fusion FISH Probe is used to confirm a fusion of the KPNB1 and SKAP1 genes. The fusion of the KPNB1 and SKAP1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| KPNB1-SKAP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| KPNB1-SKAP1-20-RERE | 20 (40 μL) | 200 μL |
|
|
| KPNB1-SKAP1-20-REOR | 20 (40 μL) | 200 μL |
|
|
| KPNB1-SKAP1-20-REGO | 20 (40 μL) | 200 μL |
|
|
| KPNB1-SKAP1-20-REGR | 20 (40 μL) | 200 μL |
|
|
| KPNB1-SKAP1-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| KPNB1-SKAP1-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| KPNB1-SKAP1-20-OROR | 20 (40 μL) | 200 μL |
|
|
| KPNB1-SKAP1-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| KPNB1-SKAP1-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| KPNB1-SKAP1-20-GORE | 20 (40 μL) | 200 μL |
|
|
| KPNB1-SKAP1-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| KPNB1-SKAP1-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| KPNB1-SKAP1-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| KPNB1-SKAP1-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| KPNB1-SKAP1-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| KPNB1-SKAP1-20-GROR | 20 (40 μL) | 200 μL |
|
|
| KPNB1-SKAP1-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| KPNB1-SKAP1-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| KPNB1-SKAP1-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| KPNB1-SKAP1-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| KPNB1-SKAP1-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| KPNB1-SKAP1-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| KPNB1-SKAP1-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| KPNB1-SKAP1-20-AQAQ | 20 (40 μL) | 200 μL |
|
KPNB1 Gene Summary
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
Gene Name: Karyopherin Subunit Beta 1
Chromosome: CHR17: 45727274 -45761004
Locus: 17q21.32
SKAP1 Gene Summary
This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. [provided by RefSeq, Jul 2008]
Gene Name: Src Kinase Associated Phosphoprotein 1
Chromosome: CHR17: 46210801 -46507594
Locus: 17q21.32
Gene Diseases
The KPNB1 SKAP1 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|