KPNA6-RHCE Fusion FISH Probe
The KPNA6-RHCE Fusion FISH Probe is used to confirm a fusion of the KPNA6 and RHCE genes. The fusion of the KPNA6 and RHCE genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KPNA6-RHCE-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KPNA6-RHCE-20-RERE | 20 (40 μL) | 200 μL |
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| KPNA6-RHCE-20-REOR | 20 (40 μL) | 200 μL |
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| KPNA6-RHCE-20-REGO | 20 (40 μL) | 200 μL |
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| KPNA6-RHCE-20-REGR | 20 (40 μL) | 200 μL |
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| KPNA6-RHCE-20-REAQ | 20 (40 μL) | 200 μL |
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| KPNA6-RHCE-20-ORRE | 20 (40 μL) | 200 μL |
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| KPNA6-RHCE-20-OROR | 20 (40 μL) | 200 μL |
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| KPNA6-RHCE-20-ORGO | 20 (40 μL) | 200 μL |
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| KPNA6-RHCE-20-ORAQ | 20 (40 μL) | 200 μL |
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| KPNA6-RHCE-20-GORE | 20 (40 μL) | 200 μL |
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| KPNA6-RHCE-20-GOOR | 20 (40 μL) | 200 μL |
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| KPNA6-RHCE-20-GOGO | 20 (40 μL) | 200 μL |
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| KPNA6-RHCE-20-GOGR | 20 (40 μL) | 200 μL |
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| KPNA6-RHCE-20-GOAQ | 20 (40 μL) | 200 μL |
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| KPNA6-RHCE-20-GRRE | 20 (40 μL) | 200 μL |
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| KPNA6-RHCE-20-GROR | 20 (40 μL) | 200 μL |
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| KPNA6-RHCE-20-GRGO | 20 (40 μL) | 200 μL |
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| KPNA6-RHCE-20-GRGR | 20 (40 μL) | 200 μL |
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| KPNA6-RHCE-20-GRAQ | 20 (40 μL) | 200 μL |
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| KPNA6-RHCE-20-AQRE | 20 (40 μL) | 200 μL |
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| KPNA6-RHCE-20-AQOR | 20 (40 μL) | 200 μL |
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| KPNA6-RHCE-20-AQGO | 20 (40 μL) | 200 μL |
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| KPNA6-RHCE-20-AQGR | 20 (40 μL) | 200 μL |
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| KPNA6-RHCE-20-AQAQ | 20 (40 μL) | 200 μL |
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RHCE Gene Summary
The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations. The Rh blood group includes this gene which encodes both the RhC and RhE antigens on a single polypeptide and a second gene which encodes the RhD protein. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. A mutation in this gene results in amorph-type Rh-null disease. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Aug 2016]
Gene Name: Rh Blood Group CcEe Antigens
Chromosome: CHR1: 25688739 -25747363
Locus: 1p36.11
KPNA6 Gene Summary
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family. [provided by RefSeq, Jul 2008]
Gene Name: Karyopherin Subunit Alpha 6
Chromosome: CHR1: 32573643 -32642168
Locus: 1p35.2
Gene Diseases
The KPNA6 RHCE Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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