KPNA4-PTPRD Fusion FISH Probe
The KPNA4-PTPRD Fusion FISH Probe is used to confirm a fusion of the KPNA4 and PTPRD genes. The fusion of the KPNA4 and PTPRD genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KPNA4-PTPRD-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KPNA4-PTPRD-20-RERE | 20 (40 μL) | 200 μL |
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| KPNA4-PTPRD-20-REOR | 20 (40 μL) | 200 μL |
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| KPNA4-PTPRD-20-REGO | 20 (40 μL) | 200 μL |
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| KPNA4-PTPRD-20-REGR | 20 (40 μL) | 200 μL |
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| KPNA4-PTPRD-20-REAQ | 20 (40 μL) | 200 μL |
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| KPNA4-PTPRD-20-ORRE | 20 (40 μL) | 200 μL |
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| KPNA4-PTPRD-20-OROR | 20 (40 μL) | 200 μL |
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| KPNA4-PTPRD-20-ORGO | 20 (40 μL) | 200 μL |
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| KPNA4-PTPRD-20-ORAQ | 20 (40 μL) | 200 μL |
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| KPNA4-PTPRD-20-GORE | 20 (40 μL) | 200 μL |
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| KPNA4-PTPRD-20-GOOR | 20 (40 μL) | 200 μL |
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| KPNA4-PTPRD-20-GOGO | 20 (40 μL) | 200 μL |
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| KPNA4-PTPRD-20-GOGR | 20 (40 μL) | 200 μL |
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| KPNA4-PTPRD-20-GOAQ | 20 (40 μL) | 200 μL |
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| KPNA4-PTPRD-20-GRRE | 20 (40 μL) | 200 μL |
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| KPNA4-PTPRD-20-GROR | 20 (40 μL) | 200 μL |
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| KPNA4-PTPRD-20-GRGO | 20 (40 μL) | 200 μL |
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| KPNA4-PTPRD-20-GRGR | 20 (40 μL) | 200 μL |
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| KPNA4-PTPRD-20-GRAQ | 20 (40 μL) | 200 μL |
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| KPNA4-PTPRD-20-AQRE | 20 (40 μL) | 200 μL |
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| KPNA4-PTPRD-20-AQOR | 20 (40 μL) | 200 μL |
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| KPNA4-PTPRD-20-AQGO | 20 (40 μL) | 200 μL |
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| KPNA4-PTPRD-20-AQGR | 20 (40 μL) | 200 μL |
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| KPNA4-PTPRD-20-AQAQ | 20 (40 μL) | 200 μL |
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KPNA4 Gene Summary
The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen. [provided by RefSeq, Jul 2008]
Gene Name: Karyopherin Subunit Alpha 4
Chromosome: CHR3: 160212782 -160283376
Locus: 3q25.33
PTPRD Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jan 2010]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type D
Chromosome: CHR9: 8314245 -10612723
Locus: 9p24.1-p23
Gene Diseases
The KPNA4 PTPRD Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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