KPNA3-FGF2 Fusion FISH Probe
The KPNA3-FGF2 Fusion FISH Probe is used to confirm a fusion of the KPNA3 and FGF2 genes. The fusion of the KPNA3 and FGF2 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KPNA3-FGF2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KPNA3-FGF2-20-RERE | 20 (40 μL) | 200 μL |
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| KPNA3-FGF2-20-REOR | 20 (40 μL) | 200 μL |
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| KPNA3-FGF2-20-REGO | 20 (40 μL) | 200 μL |
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| KPNA3-FGF2-20-REGR | 20 (40 μL) | 200 μL |
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| KPNA3-FGF2-20-REAQ | 20 (40 μL) | 200 μL |
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| KPNA3-FGF2-20-ORRE | 20 (40 μL) | 200 μL |
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| KPNA3-FGF2-20-OROR | 20 (40 μL) | 200 μL |
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| KPNA3-FGF2-20-ORGO | 20 (40 μL) | 200 μL |
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| KPNA3-FGF2-20-ORAQ | 20 (40 μL) | 200 μL |
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| KPNA3-FGF2-20-GORE | 20 (40 μL) | 200 μL |
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| KPNA3-FGF2-20-GOOR | 20 (40 μL) | 200 μL |
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| KPNA3-FGF2-20-GOGO | 20 (40 μL) | 200 μL |
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| KPNA3-FGF2-20-GOGR | 20 (40 μL) | 200 μL |
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| KPNA3-FGF2-20-GOAQ | 20 (40 μL) | 200 μL |
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| KPNA3-FGF2-20-GRRE | 20 (40 μL) | 200 μL |
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| KPNA3-FGF2-20-GROR | 20 (40 μL) | 200 μL |
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| KPNA3-FGF2-20-GRGO | 20 (40 μL) | 200 μL |
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| KPNA3-FGF2-20-GRGR | 20 (40 μL) | 200 μL |
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| KPNA3-FGF2-20-GRAQ | 20 (40 μL) | 200 μL |
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| KPNA3-FGF2-20-AQRE | 20 (40 μL) | 200 μL |
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| KPNA3-FGF2-20-AQOR | 20 (40 μL) | 200 μL |
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| KPNA3-FGF2-20-AQGO | 20 (40 μL) | 200 μL |
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| KPNA3-FGF2-20-AQGR | 20 (40 μL) | 200 μL |
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| KPNA3-FGF2-20-AQAQ | 20 (40 μL) | 200 μL |
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FGF2 Gene Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008]
Gene Name: Fibroblast Growth Factor 2
Chromosome: CHR4: 123747862 -123819390
Locus: 4q28.1
KPNA3 Gene Summary
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. [provided by RefSeq, Jan 2009]
Gene Name: Karyopherin Subunit Alpha 3
Chromosome: CHR13: 50273442 -50367057
Locus: 13q14.2
Gene Diseases
The KPNA3 FGF2 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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