KPNA1-SMC1B Fusion FISH Probe
The KPNA1-SMC1B Fusion FISH Probe is used to confirm a fusion of the KPNA1 and SMC1B genes. The fusion of the KPNA1 and SMC1B genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KPNA1-SMC1B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KPNA1-SMC1B-20-RERE | 20 (40 μL) | 200 μL |
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| KPNA1-SMC1B-20-REOR | 20 (40 μL) | 200 μL |
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| KPNA1-SMC1B-20-REGO | 20 (40 μL) | 200 μL |
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| KPNA1-SMC1B-20-REGR | 20 (40 μL) | 200 μL |
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| KPNA1-SMC1B-20-REAQ | 20 (40 μL) | 200 μL |
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| KPNA1-SMC1B-20-ORRE | 20 (40 μL) | 200 μL |
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| KPNA1-SMC1B-20-OROR | 20 (40 μL) | 200 μL |
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| KPNA1-SMC1B-20-ORGO | 20 (40 μL) | 200 μL |
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| KPNA1-SMC1B-20-ORAQ | 20 (40 μL) | 200 μL |
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| KPNA1-SMC1B-20-GORE | 20 (40 μL) | 200 μL |
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| KPNA1-SMC1B-20-GOOR | 20 (40 μL) | 200 μL |
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| KPNA1-SMC1B-20-GOGO | 20 (40 μL) | 200 μL |
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| KPNA1-SMC1B-20-GOGR | 20 (40 μL) | 200 μL |
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| KPNA1-SMC1B-20-GOAQ | 20 (40 μL) | 200 μL |
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| KPNA1-SMC1B-20-GRRE | 20 (40 μL) | 200 μL |
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| KPNA1-SMC1B-20-GROR | 20 (40 μL) | 200 μL |
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| KPNA1-SMC1B-20-GRGO | 20 (40 μL) | 200 μL |
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| KPNA1-SMC1B-20-GRGR | 20 (40 μL) | 200 μL |
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| KPNA1-SMC1B-20-GRAQ | 20 (40 μL) | 200 μL |
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| KPNA1-SMC1B-20-AQRE | 20 (40 μL) | 200 μL |
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| KPNA1-SMC1B-20-AQOR | 20 (40 μL) | 200 μL |
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| KPNA1-SMC1B-20-AQGO | 20 (40 μL) | 200 μL |
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| KPNA1-SMC1B-20-AQGR | 20 (40 μL) | 200 μL |
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| KPNA1-SMC1B-20-AQAQ | 20 (40 μL) | 200 μL |
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KPNA1 Gene Summary
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin ligase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Gene Name: Karyopherin Subunit Alpha 1
Chromosome: CHR3: 122140747 -122233786
Locus: 3q21.1
SMC1B Gene Summary
SMC1L2 belongs to a family of proteins required for chromatid cohesion and DNA recombination during meiosis and mitosis (3:Revenkova et al., 2001 [PubMed 11564881]).[supplied by OMIM, Mar 2008]
Gene Name: Structural Maintenance Of Chromosomes 1B
Chromosome: CHR22: 45739944 -45809500
Locus: 22q13.31
Gene Diseases
The KPNA1 SMC1B Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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