KPNA1-NCK1 Fusion FISH Probe
The KPNA1-NCK1 Fusion FISH Probe is used to confirm a fusion of the KPNA1 and NCK1 genes. The fusion of the KPNA1 and NCK1 genes has been associated with Mesothelioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| KPNA1-NCK1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| KPNA1-NCK1-20-RERE | 20 (40 μL) | 200 μL |
|
|
| KPNA1-NCK1-20-REOR | 20 (40 μL) | 200 μL |
|
|
| KPNA1-NCK1-20-REGO | 20 (40 μL) | 200 μL |
|
|
| KPNA1-NCK1-20-REGR | 20 (40 μL) | 200 μL |
|
|
| KPNA1-NCK1-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| KPNA1-NCK1-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| KPNA1-NCK1-20-OROR | 20 (40 μL) | 200 μL |
|
|
| KPNA1-NCK1-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| KPNA1-NCK1-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| KPNA1-NCK1-20-GORE | 20 (40 μL) | 200 μL |
|
|
| KPNA1-NCK1-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| KPNA1-NCK1-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| KPNA1-NCK1-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| KPNA1-NCK1-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| KPNA1-NCK1-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| KPNA1-NCK1-20-GROR | 20 (40 μL) | 200 μL |
|
|
| KPNA1-NCK1-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| KPNA1-NCK1-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| KPNA1-NCK1-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| KPNA1-NCK1-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| KPNA1-NCK1-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| KPNA1-NCK1-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| KPNA1-NCK1-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| KPNA1-NCK1-20-AQAQ | 20 (40 μL) | 200 μL |
|
KPNA1 Gene Summary
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin ligase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Gene Name: Karyopherin Subunit Alpha 1
Chromosome: CHR3: 122140747 -122233786
Locus: 3q21.1
NCK1 Gene Summary
The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jun 2010]
Gene Name: NCK Adaptor Protein 1
Chromosome: CHR3: 136581049 -136667968
Locus: 3q22.3
Gene Diseases
The KPNA1 NCK1 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Mesothelioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|