KPNA1-GMPS Fusion FISH Probe
The KPNA1-GMPS Fusion FISH Probe is used to confirm a fusion of the KPNA1 and GMPS genes. The fusion of the KPNA1 and GMPS genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KPNA1-GMPS-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KPNA1-GMPS-20-RERE | 20 (40 μL) | 200 μL |
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| KPNA1-GMPS-20-REOR | 20 (40 μL) | 200 μL |
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| KPNA1-GMPS-20-REGO | 20 (40 μL) | 200 μL |
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| KPNA1-GMPS-20-REGR | 20 (40 μL) | 200 μL |
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| KPNA1-GMPS-20-REAQ | 20 (40 μL) | 200 μL |
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| KPNA1-GMPS-20-ORRE | 20 (40 μL) | 200 μL |
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| KPNA1-GMPS-20-OROR | 20 (40 μL) | 200 μL |
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| KPNA1-GMPS-20-ORGO | 20 (40 μL) | 200 μL |
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| KPNA1-GMPS-20-ORAQ | 20 (40 μL) | 200 μL |
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| KPNA1-GMPS-20-GORE | 20 (40 μL) | 200 μL |
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| KPNA1-GMPS-20-GOOR | 20 (40 μL) | 200 μL |
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| KPNA1-GMPS-20-GOGO | 20 (40 μL) | 200 μL |
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| KPNA1-GMPS-20-GOGR | 20 (40 μL) | 200 μL |
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| KPNA1-GMPS-20-GOAQ | 20 (40 μL) | 200 μL |
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| KPNA1-GMPS-20-GRRE | 20 (40 μL) | 200 μL |
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| KPNA1-GMPS-20-GROR | 20 (40 μL) | 200 μL |
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| KPNA1-GMPS-20-GRGO | 20 (40 μL) | 200 μL |
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| KPNA1-GMPS-20-GRGR | 20 (40 μL) | 200 μL |
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| KPNA1-GMPS-20-GRAQ | 20 (40 μL) | 200 μL |
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| KPNA1-GMPS-20-AQRE | 20 (40 μL) | 200 μL |
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| KPNA1-GMPS-20-AQOR | 20 (40 μL) | 200 μL |
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| KPNA1-GMPS-20-AQGO | 20 (40 μL) | 200 μL |
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| KPNA1-GMPS-20-AQGR | 20 (40 μL) | 200 μL |
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| KPNA1-GMPS-20-AQAQ | 20 (40 μL) | 200 μL |
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KPNA1 Gene Summary
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin ligase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Gene Name: Karyopherin Subunit Alpha 1
Chromosome: CHR3: 122140747 -122233786
Locus: 3q21.1
GMPS Gene Summary
In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008]
Gene Name: Guanine Monophosphate Synthase
Chromosome: CHR3: 155588324 -155655520
Locus: 3q25.31
Gene Diseases
The KPNA1 GMPS Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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