KPNA1-CD86 Fusion FISH Probe
The KPNA1-CD86 Fusion FISH Probe is used to confirm a fusion of the KPNA1 and CD86 genes. The fusion of the KPNA1 and CD86 genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KPNA1-CD86-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KPNA1-CD86-20-RERE | 20 (40 μL) | 200 μL |
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| KPNA1-CD86-20-REOR | 20 (40 μL) | 200 μL |
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| KPNA1-CD86-20-REGO | 20 (40 μL) | 200 μL |
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| KPNA1-CD86-20-REGR | 20 (40 μL) | 200 μL |
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| KPNA1-CD86-20-REAQ | 20 (40 μL) | 200 μL |
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| KPNA1-CD86-20-ORRE | 20 (40 μL) | 200 μL |
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| KPNA1-CD86-20-OROR | 20 (40 μL) | 200 μL |
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| KPNA1-CD86-20-ORGO | 20 (40 μL) | 200 μL |
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| KPNA1-CD86-20-ORAQ | 20 (40 μL) | 200 μL |
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| KPNA1-CD86-20-GORE | 20 (40 μL) | 200 μL |
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| KPNA1-CD86-20-GOOR | 20 (40 μL) | 200 μL |
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| KPNA1-CD86-20-GOGO | 20 (40 μL) | 200 μL |
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| KPNA1-CD86-20-GOGR | 20 (40 μL) | 200 μL |
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| KPNA1-CD86-20-GOAQ | 20 (40 μL) | 200 μL |
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| KPNA1-CD86-20-GRRE | 20 (40 μL) | 200 μL |
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| KPNA1-CD86-20-GROR | 20 (40 μL) | 200 μL |
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| KPNA1-CD86-20-GRGO | 20 (40 μL) | 200 μL |
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| KPNA1-CD86-20-GRGR | 20 (40 μL) | 200 μL |
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| KPNA1-CD86-20-GRAQ | 20 (40 μL) | 200 μL |
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| KPNA1-CD86-20-AQRE | 20 (40 μL) | 200 μL |
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| KPNA1-CD86-20-AQOR | 20 (40 μL) | 200 μL |
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| KPNA1-CD86-20-AQGO | 20 (40 μL) | 200 μL |
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| KPNA1-CD86-20-AQGR | 20 (40 μL) | 200 μL |
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| KPNA1-CD86-20-AQAQ | 20 (40 μL) | 200 μL |
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CD86 Gene Summary
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
Gene Name: CD86 Molecule
Chromosome: CHR3: 121774208 -121839988
Locus: 3q13.33
KPNA1 Gene Summary
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin ligase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Gene Name: Karyopherin Subunit Alpha 1
Chromosome: CHR3: 122140747 -122233786
Locus: 3q21.1
Gene Diseases
The KPNA1 CD86 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Clear Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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