KLK2-STAT6 Fusion FISH Probe
The KLK2-STAT6 Fusion FISH Probe is used to confirm a fusion of the KLK2 and STAT6 genes. The fusion of the KLK2 and STAT6 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KLK2-STAT6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KLK2-STAT6-20-RERE | 20 (40 μL) | 200 μL |
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| KLK2-STAT6-20-REOR | 20 (40 μL) | 200 μL |
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| KLK2-STAT6-20-REGO | 20 (40 μL) | 200 μL |
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| KLK2-STAT6-20-REGR | 20 (40 μL) | 200 μL |
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| KLK2-STAT6-20-REAQ | 20 (40 μL) | 200 μL |
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| KLK2-STAT6-20-ORRE | 20 (40 μL) | 200 μL |
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| KLK2-STAT6-20-OROR | 20 (40 μL) | 200 μL |
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| KLK2-STAT6-20-ORGO | 20 (40 μL) | 200 μL |
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| KLK2-STAT6-20-ORAQ | 20 (40 μL) | 200 μL |
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| KLK2-STAT6-20-GORE | 20 (40 μL) | 200 μL |
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| KLK2-STAT6-20-GOOR | 20 (40 μL) | 200 μL |
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| KLK2-STAT6-20-GOGO | 20 (40 μL) | 200 μL |
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| KLK2-STAT6-20-GOGR | 20 (40 μL) | 200 μL |
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| KLK2-STAT6-20-GOAQ | 20 (40 μL) | 200 μL |
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| KLK2-STAT6-20-GRRE | 20 (40 μL) | 200 μL |
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| KLK2-STAT6-20-GROR | 20 (40 μL) | 200 μL |
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| KLK2-STAT6-20-GRGO | 20 (40 μL) | 200 μL |
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| KLK2-STAT6-20-GRGR | 20 (40 μL) | 200 μL |
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| KLK2-STAT6-20-GRAQ | 20 (40 μL) | 200 μL |
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| KLK2-STAT6-20-AQRE | 20 (40 μL) | 200 μL |
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| KLK2-STAT6-20-AQOR | 20 (40 μL) | 200 μL |
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| KLK2-STAT6-20-AQGO | 20 (40 μL) | 200 μL |
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| KLK2-STAT6-20-AQGR | 20 (40 μL) | 200 μL |
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| KLK2-STAT6-20-AQAQ | 20 (40 μL) | 200 μL |
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KLK2 Gene Summary
This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Jan 2012]
Gene Name: Kallikrein Related Peptidase 2
Chromosome: CHR19: 51376688 -51383823
Locus: 19q13.33
STAT6 Gene Summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Name: Signal Transducer And Activator Of Transcription 6
Chromosome: CHR12: 57489186 -57505196
Locus: 12q13.3
Gene Diseases
The KLK2 STAT6 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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