KLK2-PLAT Fusion FISH Probe
The KLK2-PLAT Fusion FISH Probe is used to confirm a fusion of the KLK2 and PLAT genes. The fusion of the KLK2 and PLAT genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| KLK2-PLAT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| KLK2-PLAT-20-RERE | 20 (40 μL) | 200 μL |
|
|
| KLK2-PLAT-20-REOR | 20 (40 μL) | 200 μL |
|
|
| KLK2-PLAT-20-REGO | 20 (40 μL) | 200 μL |
|
|
| KLK2-PLAT-20-REGR | 20 (40 μL) | 200 μL |
|
|
| KLK2-PLAT-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| KLK2-PLAT-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| KLK2-PLAT-20-OROR | 20 (40 μL) | 200 μL |
|
|
| KLK2-PLAT-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| KLK2-PLAT-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| KLK2-PLAT-20-GORE | 20 (40 μL) | 200 μL |
|
|
| KLK2-PLAT-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| KLK2-PLAT-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| KLK2-PLAT-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| KLK2-PLAT-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| KLK2-PLAT-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| KLK2-PLAT-20-GROR | 20 (40 μL) | 200 μL |
|
|
| KLK2-PLAT-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| KLK2-PLAT-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| KLK2-PLAT-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| KLK2-PLAT-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| KLK2-PLAT-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| KLK2-PLAT-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| KLK2-PLAT-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| KLK2-PLAT-20-AQAQ | 20 (40 μL) | 200 μL |
|
KLK2 Gene Summary
This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Jan 2012]
Gene Name: Kallikrein Related Peptidase 2
Chromosome: CHR19: 51376688 -51383823
Locus: 19q13.33
PLAT Gene Summary
This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Gene Name: Plasminogen Activator, Tissue Type
Chromosome: CHR8: 42032235 -42065194
Locus: 8p11.21
Gene Diseases
The KLK2 PLAT Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|