KLK2-NDUFV1 Fusion FISH Probe
The KLK2-NDUFV1 Fusion FISH Probe is used to confirm a fusion of the KLK2 and NDUFV1 genes. The fusion of the KLK2 and NDUFV1 genes has been associated with Prostate Adenocarcinoma, and Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KLK2-NDUFV1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KLK2-NDUFV1-20-RERE | 20 (40 μL) | 200 μL |
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| KLK2-NDUFV1-20-REOR | 20 (40 μL) | 200 μL |
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| KLK2-NDUFV1-20-REGO | 20 (40 μL) | 200 μL |
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| KLK2-NDUFV1-20-REGR | 20 (40 μL) | 200 μL |
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| KLK2-NDUFV1-20-REAQ | 20 (40 μL) | 200 μL |
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| KLK2-NDUFV1-20-ORRE | 20 (40 μL) | 200 μL |
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| KLK2-NDUFV1-20-OROR | 20 (40 μL) | 200 μL |
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| KLK2-NDUFV1-20-ORGO | 20 (40 μL) | 200 μL |
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| KLK2-NDUFV1-20-ORAQ | 20 (40 μL) | 200 μL |
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| KLK2-NDUFV1-20-GORE | 20 (40 μL) | 200 μL |
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| KLK2-NDUFV1-20-GOOR | 20 (40 μL) | 200 μL |
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| KLK2-NDUFV1-20-GOGO | 20 (40 μL) | 200 μL |
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| KLK2-NDUFV1-20-GOGR | 20 (40 μL) | 200 μL |
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| KLK2-NDUFV1-20-GOAQ | 20 (40 μL) | 200 μL |
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| KLK2-NDUFV1-20-GRRE | 20 (40 μL) | 200 μL |
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| KLK2-NDUFV1-20-GROR | 20 (40 μL) | 200 μL |
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| KLK2-NDUFV1-20-GRGO | 20 (40 μL) | 200 μL |
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| KLK2-NDUFV1-20-GRGR | 20 (40 μL) | 200 μL |
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| KLK2-NDUFV1-20-GRAQ | 20 (40 μL) | 200 μL |
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| KLK2-NDUFV1-20-AQRE | 20 (40 μL) | 200 μL |
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| KLK2-NDUFV1-20-AQOR | 20 (40 μL) | 200 μL |
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| KLK2-NDUFV1-20-AQGO | 20 (40 μL) | 200 μL |
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| KLK2-NDUFV1-20-AQGR | 20 (40 μL) | 200 μL |
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| KLK2-NDUFV1-20-AQAQ | 20 (40 μL) | 200 μL |
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KLK2 Gene Summary
This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Jan 2012]
Gene Name: Kallikrein Related Peptidase 2
Chromosome: CHR19: 51376688 -51383823
Locus: 19q13.33
NDUFV1 Gene Summary
The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10,000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinson's disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
Gene Name: NADH:ubiquinone Oxidoreductase Core Subunit V1
Chromosome: CHR11: 67374322 -67380012
Locus: 11q13.2
Gene Diseases
The KLK2 NDUFV1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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