KLK2-FGFR2 Fusion FISH Probe
The KLK2-FGFR2 Fusion FISH Probe is used to confirm a fusion of the KLK2 and FGFR2 genes. The fusion of the KLK2 and FGFR2 genes has been associated with Prostate Adenocarcinoma, Prostate Adenocarcinoma, and Uveal Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KLK2-FGFR2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KLK2-FGFR2-20-RERE | 20 (40 μL) | 200 μL |
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| KLK2-FGFR2-20-REOR | 20 (40 μL) | 200 μL |
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| KLK2-FGFR2-20-REGO | 20 (40 μL) | 200 μL |
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| KLK2-FGFR2-20-REGR | 20 (40 μL) | 200 μL |
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| KLK2-FGFR2-20-REAQ | 20 (40 μL) | 200 μL |
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| KLK2-FGFR2-20-ORRE | 20 (40 μL) | 200 μL |
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| KLK2-FGFR2-20-OROR | 20 (40 μL) | 200 μL |
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| KLK2-FGFR2-20-ORGO | 20 (40 μL) | 200 μL |
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| KLK2-FGFR2-20-ORAQ | 20 (40 μL) | 200 μL |
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| KLK2-FGFR2-20-GORE | 20 (40 μL) | 200 μL |
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| KLK2-FGFR2-20-GOOR | 20 (40 μL) | 200 μL |
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| KLK2-FGFR2-20-GOGO | 20 (40 μL) | 200 μL |
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| KLK2-FGFR2-20-GOGR | 20 (40 μL) | 200 μL |
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| KLK2-FGFR2-20-GOAQ | 20 (40 μL) | 200 μL |
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| KLK2-FGFR2-20-GRRE | 20 (40 μL) | 200 μL |
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| KLK2-FGFR2-20-GROR | 20 (40 μL) | 200 μL |
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| KLK2-FGFR2-20-GRGO | 20 (40 μL) | 200 μL |
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| KLK2-FGFR2-20-GRGR | 20 (40 μL) | 200 μL |
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| KLK2-FGFR2-20-GRAQ | 20 (40 μL) | 200 μL |
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| KLK2-FGFR2-20-AQRE | 20 (40 μL) | 200 μL |
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| KLK2-FGFR2-20-AQOR | 20 (40 μL) | 200 μL |
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| KLK2-FGFR2-20-AQGO | 20 (40 μL) | 200 μL |
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| KLK2-FGFR2-20-AQGR | 20 (40 μL) | 200 μL |
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| KLK2-FGFR2-20-AQAQ | 20 (40 μL) | 200 μL |
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FGFR2 Gene Summary
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
Gene Name: Fibroblast Growth Factor Receptor 2
Chromosome: CHR10: 123237843 -123357972
Locus: 10q26.13
KLK2 Gene Summary
This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Jan 2012]
Gene Name: Kallikrein Related Peptidase 2
Chromosome: CHR19: 51376688 -51383823
Locus: 19q13.33
Gene Diseases
The KLK2 FGFR2 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
| Prostate Adenocarcinoma |
| Uveal Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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