KLK2-ETV1 Fusion FISH Probe
The KLK2-ETV1 Fusion FISH Probe is used to confirm a fusion of the KLK2 and ETV1 genes. The fusion of the KLK2 and ETV1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KLK2-ETV1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KLK2-ETV1-20-RERE | 20 (40 μL) | 200 μL |
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| KLK2-ETV1-20-REOR | 20 (40 μL) | 200 μL |
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| KLK2-ETV1-20-REGO | 20 (40 μL) | 200 μL |
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| KLK2-ETV1-20-REGR | 20 (40 μL) | 200 μL |
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| KLK2-ETV1-20-REAQ | 20 (40 μL) | 200 μL |
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| KLK2-ETV1-20-ORRE | 20 (40 μL) | 200 μL |
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| KLK2-ETV1-20-OROR | 20 (40 μL) | 200 μL |
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| KLK2-ETV1-20-ORGO | 20 (40 μL) | 200 μL |
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| KLK2-ETV1-20-ORAQ | 20 (40 μL) | 200 μL |
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| KLK2-ETV1-20-GORE | 20 (40 μL) | 200 μL |
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| KLK2-ETV1-20-GOOR | 20 (40 μL) | 200 μL |
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| KLK2-ETV1-20-GOGO | 20 (40 μL) | 200 μL |
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| KLK2-ETV1-20-GOGR | 20 (40 μL) | 200 μL |
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| KLK2-ETV1-20-GOAQ | 20 (40 μL) | 200 μL |
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| KLK2-ETV1-20-GRRE | 20 (40 μL) | 200 μL |
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| KLK2-ETV1-20-GROR | 20 (40 μL) | 200 μL |
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| KLK2-ETV1-20-GRGO | 20 (40 μL) | 200 μL |
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| KLK2-ETV1-20-GRGR | 20 (40 μL) | 200 μL |
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| KLK2-ETV1-20-GRAQ | 20 (40 μL) | 200 μL |
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| KLK2-ETV1-20-AQRE | 20 (40 μL) | 200 μL |
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| KLK2-ETV1-20-AQOR | 20 (40 μL) | 200 μL |
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| KLK2-ETV1-20-AQGO | 20 (40 μL) | 200 μL |
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| KLK2-ETV1-20-AQGR | 20 (40 μL) | 200 μL |
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| KLK2-ETV1-20-AQAQ | 20 (40 μL) | 200 μL |
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ETV1 Gene Summary
This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2016]
Gene Name: ETS Variant 1
Chromosome: CHR7: 13930855 -14031050
Locus: 7p21.2
KLK2 Gene Summary
This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Jan 2012]
Gene Name: Kallikrein Related Peptidase 2
Chromosome: CHR19: 51376688 -51383823
Locus: 19q13.33
Gene Diseases
The KLK2 ETV1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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