KLHL5-HLA-F Fusion FISH Probe
The KLHL5-HLA-F Fusion FISH Probe is used to confirm a fusion of the KLHL5 and HLA-F genes. The fusion of the KLHL5 and HLA-F genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KLHL5-HLA-F-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KLHL5-HLA-F-20-RERE | 20 (40 μL) | 200 μL |
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| KLHL5-HLA-F-20-REOR | 20 (40 μL) | 200 μL |
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| KLHL5-HLA-F-20-REGO | 20 (40 μL) | 200 μL |
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| KLHL5-HLA-F-20-REGR | 20 (40 μL) | 200 μL |
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| KLHL5-HLA-F-20-REAQ | 20 (40 μL) | 200 μL |
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| KLHL5-HLA-F-20-ORRE | 20 (40 μL) | 200 μL |
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| KLHL5-HLA-F-20-OROR | 20 (40 μL) | 200 μL |
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| KLHL5-HLA-F-20-ORGO | 20 (40 μL) | 200 μL |
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| KLHL5-HLA-F-20-ORAQ | 20 (40 μL) | 200 μL |
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| KLHL5-HLA-F-20-GORE | 20 (40 μL) | 200 μL |
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| KLHL5-HLA-F-20-GOOR | 20 (40 μL) | 200 μL |
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| KLHL5-HLA-F-20-GOGO | 20 (40 μL) | 200 μL |
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| KLHL5-HLA-F-20-GOGR | 20 (40 μL) | 200 μL |
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| KLHL5-HLA-F-20-GOAQ | 20 (40 μL) | 200 μL |
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| KLHL5-HLA-F-20-GRRE | 20 (40 μL) | 200 μL |
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| KLHL5-HLA-F-20-GROR | 20 (40 μL) | 200 μL |
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| KLHL5-HLA-F-20-GRGO | 20 (40 μL) | 200 μL |
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| KLHL5-HLA-F-20-GRGR | 20 (40 μL) | 200 μL |
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| KLHL5-HLA-F-20-GRAQ | 20 (40 μL) | 200 μL |
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| KLHL5-HLA-F-20-AQRE | 20 (40 μL) | 200 μL |
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| KLHL5-HLA-F-20-AQOR | 20 (40 μL) | 200 μL |
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| KLHL5-HLA-F-20-AQGO | 20 (40 μL) | 200 μL |
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| KLHL5-HLA-F-20-AQGR | 20 (40 μL) | 200 μL |
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| KLHL5-HLA-F-20-AQAQ | 20 (40 μL) | 200 μL |
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HLA-F Gene Summary
This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. [provided by RefSeq, Jul 2008]
Gene Name: Major Histocompatibility Complex, Class I, F
Chromosome: CHR6_mcf_hap5: 991650 -1359214
Locus: 6p22.1
KLHL5 Gene Summary
The Kelch Like Family Member 5 (KLHL5) gene is located on chr4 :39046450-39127853 at 4p14.
Gene Name: Kelch Like Family Member 5
Chromosome: CHR4: 39046450 -39127853
Locus: 4p14
Gene Diseases
The KLHL5 HLA-F Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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