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KLHL24-ATP11B Fusion FISH Probe

The KLHL24-ATP11B Fusion FISH Probe is used to confirm a fusion of the KLHL24 and ATP11B genes. The fusion of the KLHL24 and ATP11B genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
KLHL24-ATP11B-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
KLHL24-ATP11B-20-RERE 20 (40 μL) 200 μL
KLHL24-ATP11B-20-REOR 20 (40 μL) 200 μL
KLHL24-ATP11B-20-REGO 20 (40 μL) 200 μL
KLHL24-ATP11B-20-REGR 20 (40 μL) 200 μL
KLHL24-ATP11B-20-REAQ 20 (40 μL) 200 μL
KLHL24-ATP11B-20-ORRE 20 (40 μL) 200 μL
KLHL24-ATP11B-20-OROR 20 (40 μL) 200 μL
KLHL24-ATP11B-20-ORGO 20 (40 μL) 200 μL
KLHL24-ATP11B-20-ORAQ 20 (40 μL) 200 μL
KLHL24-ATP11B-20-GORE 20 (40 μL) 200 μL
KLHL24-ATP11B-20-GOOR 20 (40 μL) 200 μL
KLHL24-ATP11B-20-GOGO 20 (40 μL) 200 μL
KLHL24-ATP11B-20-GOGR 20 (40 μL) 200 μL
KLHL24-ATP11B-20-GOAQ 20 (40 μL) 200 μL
KLHL24-ATP11B-20-GRRE 20 (40 μL) 200 μL
KLHL24-ATP11B-20-GROR 20 (40 μL) 200 μL
KLHL24-ATP11B-20-GRGO 20 (40 μL) 200 μL
KLHL24-ATP11B-20-GRGR 20 (40 μL) 200 μL
KLHL24-ATP11B-20-GRAQ 20 (40 μL) 200 μL
KLHL24-ATP11B-20-AQRE 20 (40 μL) 200 μL
KLHL24-ATP11B-20-AQOR 20 (40 μL) 200 μL
KLHL24-ATP11B-20-AQGO 20 (40 μL) 200 μL
KLHL24-ATP11B-20-AQGR 20 (40 μL) 200 μL
KLHL24-ATP11B-20-AQAQ 20 (40 μL) 200 μL

ATP11B Gene Summary

P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily transports heavy metal ions, such as Cu(2+) or Cd(2+). Another subfamily transports non-heavy metal ions, such as H(+), Na(+), K(+), or Ca(+). A third subfamily transports amphipaths, such as phosphatidylserine.[supplied by OMIM, Feb 2005]

Gene Name: ATPase Phospholipid Transporting 11B (putative)

Chromosome: CHR3: 182511290 -182639421

Locus: 3q26.33

KLHL24 Gene Summary

The protein encoded by this gene is a ubiquitin ligase substrate receptor and is regulated by autoubiquitination. Variations in the translation initiation codon of this gene have been found, which result in an N-terminally truncated but more stable protein due to loss of the autoubiquitination function. The more stable mutant protein causes an increased ubiquitin and degradation of keratin 14, which leads to skin fragility and the potentially life-threatening disease epidermolysis bullosa. The encoded protein is also involved in the regulation of kainate receptors. [provided by RefSeq, Mar 2017]

Gene Name: Kelch Like Family Member 24

Chromosome: CHR3: 183353410 -183402304

Locus: 3q27.1

Gene Diseases

The KLHL24 ATP11B Fusion has been associated with the following diseases:

Disease Name
Kidney Renal Papillary Cell Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.