KLF5-PIBF1 Fusion FISH Probe
The KLF5-PIBF1 Fusion FISH Probe is used to confirm a fusion of the KLF5 and PIBF1 genes. The fusion of the KLF5 and PIBF1 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma, Esophageal Carcinoma, and Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KLF5-PIBF1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KLF5-PIBF1-20-RERE | 20 (40 μL) | 200 μL |
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| KLF5-PIBF1-20-REOR | 20 (40 μL) | 200 μL |
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| KLF5-PIBF1-20-REGO | 20 (40 μL) | 200 μL |
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| KLF5-PIBF1-20-REGR | 20 (40 μL) | 200 μL |
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| KLF5-PIBF1-20-REAQ | 20 (40 μL) | 200 μL |
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| KLF5-PIBF1-20-ORRE | 20 (40 μL) | 200 μL |
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| KLF5-PIBF1-20-OROR | 20 (40 μL) | 200 μL |
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| KLF5-PIBF1-20-ORGO | 20 (40 μL) | 200 μL |
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| KLF5-PIBF1-20-ORAQ | 20 (40 μL) | 200 μL |
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| KLF5-PIBF1-20-GORE | 20 (40 μL) | 200 μL |
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| KLF5-PIBF1-20-GOOR | 20 (40 μL) | 200 μL |
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| KLF5-PIBF1-20-GOGO | 20 (40 μL) | 200 μL |
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| KLF5-PIBF1-20-GOGR | 20 (40 μL) | 200 μL |
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| KLF5-PIBF1-20-GOAQ | 20 (40 μL) | 200 μL |
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| KLF5-PIBF1-20-GRRE | 20 (40 μL) | 200 μL |
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| KLF5-PIBF1-20-GROR | 20 (40 μL) | 200 μL |
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| KLF5-PIBF1-20-GRGO | 20 (40 μL) | 200 μL |
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| KLF5-PIBF1-20-GRGR | 20 (40 μL) | 200 μL |
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| KLF5-PIBF1-20-GRAQ | 20 (40 μL) | 200 μL |
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| KLF5-PIBF1-20-AQRE | 20 (40 μL) | 200 μL |
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| KLF5-PIBF1-20-AQOR | 20 (40 μL) | 200 μL |
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| KLF5-PIBF1-20-AQGO | 20 (40 μL) | 200 μL |
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| KLF5-PIBF1-20-AQGR | 20 (40 μL) | 200 μL |
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| KLF5-PIBF1-20-AQAQ | 20 (40 μL) | 200 μL |
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KLF5 Gene Summary
This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Gene Name: Kruppel Like Factor 5
Chromosome: CHR13: 73633141 -73651676
Locus: 13q22.1
PIBF1 Gene Summary
This gene encodes a protein that is induced by the steroid hormone progesterone and plays a role in the maintenance of pregnancy. The encoded protein regulates multiple facets of the immune system to promote normal pregnancy including cytokine synthesis, natural killer (NK) cell activity, and arachidonic acid metabolism. Low serum levels of this protein have been associated with spontaneous pre-term labor in humans. This protein may promote the proliferation, migration and invasion of glioma. [provided by RefSeq, Mar 2017]
Gene Name: Progesterone Immunomodulatory Binding Factor 1
Chromosome: CHR13: 73356229 -73590591
Locus: 13q21.33-q22.1
Gene Diseases
The KLF5 PIBF1 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
| Esophageal Carcinoma |
| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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