KIT-HOPX Fusion FISH Probe
The KIT-HOPX Fusion FISH Probe is used to confirm a fusion of the KIT and HOPX genes. The fusion of the KIT and HOPX genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KIT-HOPX-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KIT-HOPX-20-RERE | 20 (40 μL) | 200 μL |
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| KIT-HOPX-20-REOR | 20 (40 μL) | 200 μL |
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| KIT-HOPX-20-REGO | 20 (40 μL) | 200 μL |
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| KIT-HOPX-20-REGR | 20 (40 μL) | 200 μL |
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| KIT-HOPX-20-REAQ | 20 (40 μL) | 200 μL |
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| KIT-HOPX-20-ORRE | 20 (40 μL) | 200 μL |
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| KIT-HOPX-20-OROR | 20 (40 μL) | 200 μL |
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| KIT-HOPX-20-ORGO | 20 (40 μL) | 200 μL |
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| KIT-HOPX-20-ORAQ | 20 (40 μL) | 200 μL |
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| KIT-HOPX-20-GORE | 20 (40 μL) | 200 μL |
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| KIT-HOPX-20-GOOR | 20 (40 μL) | 200 μL |
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| KIT-HOPX-20-GOGO | 20 (40 μL) | 200 μL |
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| KIT-HOPX-20-GOGR | 20 (40 μL) | 200 μL |
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| KIT-HOPX-20-GOAQ | 20 (40 μL) | 200 μL |
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| KIT-HOPX-20-GRRE | 20 (40 μL) | 200 μL |
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| KIT-HOPX-20-GROR | 20 (40 μL) | 200 μL |
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| KIT-HOPX-20-GRGO | 20 (40 μL) | 200 μL |
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| KIT-HOPX-20-GRGR | 20 (40 μL) | 200 μL |
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| KIT-HOPX-20-GRAQ | 20 (40 μL) | 200 μL |
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| KIT-HOPX-20-AQRE | 20 (40 μL) | 200 μL |
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| KIT-HOPX-20-AQOR | 20 (40 μL) | 200 μL |
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| KIT-HOPX-20-AQGO | 20 (40 μL) | 200 μL |
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| KIT-HOPX-20-AQGR | 20 (40 μL) | 200 μL |
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| KIT-HOPX-20-AQAQ | 20 (40 μL) | 200 μL |
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KIT Gene Summary
This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: KIT Proto-oncogene Receptor Tyrosine Kinase
Chromosome: CHR4: 55524094 -55606881
Locus: 4q12
HOPX Gene Summary
The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Feb 2009]
Gene Name: HOP Homeobox
Chromosome: CHR4: 57514153 -57547872
Locus: 4q12
Gene Diseases
The KIT HOPX Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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