KIF5C-TTN Fusion FISH Probe
The KIF5C-TTN Fusion FISH Probe is used to confirm a fusion of the KIF5C and TTN genes. The fusion of the KIF5C and TTN genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KIF5C-TTN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KIF5C-TTN-20-RERE | 20 (40 μL) | 200 μL |
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| KIF5C-TTN-20-REOR | 20 (40 μL) | 200 μL |
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| KIF5C-TTN-20-REGO | 20 (40 μL) | 200 μL |
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| KIF5C-TTN-20-REGR | 20 (40 μL) | 200 μL |
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| KIF5C-TTN-20-REAQ | 20 (40 μL) | 200 μL |
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| KIF5C-TTN-20-ORRE | 20 (40 μL) | 200 μL |
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| KIF5C-TTN-20-OROR | 20 (40 μL) | 200 μL |
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| KIF5C-TTN-20-ORGO | 20 (40 μL) | 200 μL |
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| KIF5C-TTN-20-ORAQ | 20 (40 μL) | 200 μL |
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| KIF5C-TTN-20-GORE | 20 (40 μL) | 200 μL |
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| KIF5C-TTN-20-GOOR | 20 (40 μL) | 200 μL |
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| KIF5C-TTN-20-GOGO | 20 (40 μL) | 200 μL |
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| KIF5C-TTN-20-GOGR | 20 (40 μL) | 200 μL |
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| KIF5C-TTN-20-GOAQ | 20 (40 μL) | 200 μL |
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| KIF5C-TTN-20-GRRE | 20 (40 μL) | 200 μL |
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| KIF5C-TTN-20-GROR | 20 (40 μL) | 200 μL |
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| KIF5C-TTN-20-GRGO | 20 (40 μL) | 200 μL |
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| KIF5C-TTN-20-GRGR | 20 (40 μL) | 200 μL |
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| KIF5C-TTN-20-GRAQ | 20 (40 μL) | 200 μL |
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| KIF5C-TTN-20-AQRE | 20 (40 μL) | 200 μL |
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| KIF5C-TTN-20-AQOR | 20 (40 μL) | 200 μL |
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| KIF5C-TTN-20-AQGO | 20 (40 μL) | 200 μL |
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| KIF5C-TTN-20-AQGR | 20 (40 μL) | 200 μL |
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| KIF5C-TTN-20-AQAQ | 20 (40 μL) | 200 μL |
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KIF5C Gene Summary
The protein encoded by this gene is a kinesin heavy chain subunit involved in the transport of cargo within the central nervous system. The encoded protein, which acts as a tetramer by associating with another heavy chain and two light chains, interacts with protein kinase CK2. Mutations in this gene have been associated with complex cortical dysplasia with other brain malformations-2. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Jul 2015]
Gene Name: Kinesin Family Member 5C
Chromosome: CHR2: 149632818 -149883273
Locus: 2q23.1-q23.2
TTN Gene Summary
This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma. [provided by RefSeq, Feb 2012]
Gene Name: Titin
Chromosome: CHR2: 179390717 -179672150
Locus: 2q31.2
Gene Diseases
The KIF5C TTN Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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