KIF21B-F13B Fusion FISH Probe
The KIF21B-F13B Fusion FISH Probe is used to confirm a fusion of the KIF21B and F13B genes. The fusion of the KIF21B and F13B genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KIF21B-F13B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KIF21B-F13B-20-RERE | 20 (40 μL) | 200 μL |
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| KIF21B-F13B-20-REOR | 20 (40 μL) | 200 μL |
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| KIF21B-F13B-20-REGO | 20 (40 μL) | 200 μL |
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| KIF21B-F13B-20-REGR | 20 (40 μL) | 200 μL |
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| KIF21B-F13B-20-REAQ | 20 (40 μL) | 200 μL |
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| KIF21B-F13B-20-ORRE | 20 (40 μL) | 200 μL |
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| KIF21B-F13B-20-OROR | 20 (40 μL) | 200 μL |
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| KIF21B-F13B-20-ORGO | 20 (40 μL) | 200 μL |
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| KIF21B-F13B-20-ORAQ | 20 (40 μL) | 200 μL |
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| KIF21B-F13B-20-GORE | 20 (40 μL) | 200 μL |
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| KIF21B-F13B-20-GOOR | 20 (40 μL) | 200 μL |
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| KIF21B-F13B-20-GOGO | 20 (40 μL) | 200 μL |
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| KIF21B-F13B-20-GOGR | 20 (40 μL) | 200 μL |
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| KIF21B-F13B-20-GOAQ | 20 (40 μL) | 200 μL |
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| KIF21B-F13B-20-GRRE | 20 (40 μL) | 200 μL |
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| KIF21B-F13B-20-GROR | 20 (40 μL) | 200 μL |
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| KIF21B-F13B-20-GRGO | 20 (40 μL) | 200 μL |
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| KIF21B-F13B-20-GRGR | 20 (40 μL) | 200 μL |
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| KIF21B-F13B-20-GRAQ | 20 (40 μL) | 200 μL |
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| KIF21B-F13B-20-AQRE | 20 (40 μL) | 200 μL |
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| KIF21B-F13B-20-AQOR | 20 (40 μL) | 200 μL |
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| KIF21B-F13B-20-AQGO | 20 (40 μL) | 200 μL |
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| KIF21B-F13B-20-AQGR | 20 (40 μL) | 200 μL |
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| KIF21B-F13B-20-AQAQ | 20 (40 μL) | 200 μL |
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F13B Gene Summary
This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]
Gene Name: Coagulation Factor XIII B Chain
Chromosome: CHR1: 197008320 -197036397
Locus: 1q31.3
KIF21B Gene Summary
This gene encodes a member of the kinesin superfamily. Kinesins are ATP-dependent microtubule-based motor proteins that are involved in the intracellular transport of membranous organelles. Single nucleotide polymorphisms in this gene are associated with inflammatory bowel disease and multiple sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Gene Name: Kinesin Family Member 21B
Chromosome: CHR1: 200938519 -200992828
Locus: 1q32.1
Gene Diseases
The KIF21B F13B Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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