KIF13A-TPMT Fusion FISH Probe
The KIF13A-TPMT Fusion FISH Probe is used to confirm a fusion of the KIF13A and TPMT genes. The fusion of the KIF13A and TPMT genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KIF13A-TPMT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KIF13A-TPMT-20-RERE | 20 (40 μL) | 200 μL |
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| KIF13A-TPMT-20-REOR | 20 (40 μL) | 200 μL |
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| KIF13A-TPMT-20-REGO | 20 (40 μL) | 200 μL |
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| KIF13A-TPMT-20-REGR | 20 (40 μL) | 200 μL |
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| KIF13A-TPMT-20-REAQ | 20 (40 μL) | 200 μL |
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| KIF13A-TPMT-20-ORRE | 20 (40 μL) | 200 μL |
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| KIF13A-TPMT-20-OROR | 20 (40 μL) | 200 μL |
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| KIF13A-TPMT-20-ORGO | 20 (40 μL) | 200 μL |
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| KIF13A-TPMT-20-ORAQ | 20 (40 μL) | 200 μL |
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| KIF13A-TPMT-20-GORE | 20 (40 μL) | 200 μL |
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| KIF13A-TPMT-20-GOOR | 20 (40 μL) | 200 μL |
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| KIF13A-TPMT-20-GOGO | 20 (40 μL) | 200 μL |
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| KIF13A-TPMT-20-GOGR | 20 (40 μL) | 200 μL |
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| KIF13A-TPMT-20-GOAQ | 20 (40 μL) | 200 μL |
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| KIF13A-TPMT-20-GRRE | 20 (40 μL) | 200 μL |
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| KIF13A-TPMT-20-GROR | 20 (40 μL) | 200 μL |
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| KIF13A-TPMT-20-GRGO | 20 (40 μL) | 200 μL |
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| KIF13A-TPMT-20-GRGR | 20 (40 μL) | 200 μL |
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| KIF13A-TPMT-20-GRAQ | 20 (40 μL) | 200 μL |
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| KIF13A-TPMT-20-AQRE | 20 (40 μL) | 200 μL |
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| KIF13A-TPMT-20-AQOR | 20 (40 μL) | 200 μL |
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| KIF13A-TPMT-20-AQGO | 20 (40 μL) | 200 μL |
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| KIF13A-TPMT-20-AQGR | 20 (40 μL) | 200 μL |
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| KIF13A-TPMT-20-AQAQ | 20 (40 μL) | 200 μL |
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TPMT Gene Summary
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014]
Gene Name: Thiopurine S-methyltransferase
Chromosome: CHR6: 18128544 -18155374
Locus: 6p22.3
KIF13A Gene Summary
This gene encodes a member of the kinesin family of microtubule-based motor proteins that function in the positioning of endosomes. This family member can direct mannose-6-phosphate receptor-containing vesicles from the trans-Golgi network to the plasma membrane, and it is necessary for the steady-state distribution of late endosomes/lysosomes. It is also required for the translocation of FYVE-CENT and TTC19 from the centrosome to the midbody during cytokinesis, and it plays a role in melanosome maturation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Gene Name: Kinesin Family Member 13A
Chromosome: CHR6: 17759413 -17987854
Locus: 6p22.3
Gene Diseases
The KIF13A TPMT Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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