KIDINS220-MYT1L Fusion FISH Probe
The KIDINS220-MYT1L Fusion FISH Probe is used to confirm a fusion of the KIDINS220 and MYT1L genes. The fusion of the KIDINS220 and MYT1L genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KIDINS220-MYT1L-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KIDINS220-MYT1L-20-RERE | 20 (40 μL) | 200 μL |
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| KIDINS220-MYT1L-20-REOR | 20 (40 μL) | 200 μL |
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| KIDINS220-MYT1L-20-REGO | 20 (40 μL) | 200 μL |
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| KIDINS220-MYT1L-20-REGR | 20 (40 μL) | 200 μL |
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| KIDINS220-MYT1L-20-REAQ | 20 (40 μL) | 200 μL |
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| KIDINS220-MYT1L-20-ORRE | 20 (40 μL) | 200 μL |
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| KIDINS220-MYT1L-20-OROR | 20 (40 μL) | 200 μL |
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| KIDINS220-MYT1L-20-ORGO | 20 (40 μL) | 200 μL |
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| KIDINS220-MYT1L-20-ORAQ | 20 (40 μL) | 200 μL |
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| KIDINS220-MYT1L-20-GORE | 20 (40 μL) | 200 μL |
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| KIDINS220-MYT1L-20-GOOR | 20 (40 μL) | 200 μL |
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| KIDINS220-MYT1L-20-GOGO | 20 (40 μL) | 200 μL |
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| KIDINS220-MYT1L-20-GOGR | 20 (40 μL) | 200 μL |
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| KIDINS220-MYT1L-20-GOAQ | 20 (40 μL) | 200 μL |
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| KIDINS220-MYT1L-20-GRRE | 20 (40 μL) | 200 μL |
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| KIDINS220-MYT1L-20-GROR | 20 (40 μL) | 200 μL |
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| KIDINS220-MYT1L-20-GRGO | 20 (40 μL) | 200 μL |
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| KIDINS220-MYT1L-20-GRGR | 20 (40 μL) | 200 μL |
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| KIDINS220-MYT1L-20-GRAQ | 20 (40 μL) | 200 μL |
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| KIDINS220-MYT1L-20-AQRE | 20 (40 μL) | 200 μL |
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| KIDINS220-MYT1L-20-AQOR | 20 (40 μL) | 200 μL |
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| KIDINS220-MYT1L-20-AQGO | 20 (40 μL) | 200 μL |
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| KIDINS220-MYT1L-20-AQGR | 20 (40 μL) | 200 μL |
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| KIDINS220-MYT1L-20-AQAQ | 20 (40 μL) | 200 μL |
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MYT1L Gene Summary
This gene encodes a member of the zinc finger superfamily of transcription factors whose expression, thus far, has been found only in neuronal tissues. The encoded protein belongs to a novel class of cystein-cystein-histidine-cystein zinc finger proteins that function in the developing mammalian central nervous system. Forced expression of this gene in combination with the basic helix-loop-helix transcription factor NeuroD1 and the transcription factors POU class 3 homeobox 2 and achaete-scute family basic helix-loop-helix transcription factor 1 can convert fetal and postnatal human fibroblasts into induced neuronal cells, which are able to generate action potentials. Mutations in this gene have been associated with an autosomal dominant form of cognitive disability and with autism spectrum disorder. Alternative splicing results in multiple variants. [provided by RefSeq, Jul 2017]
Gene Name: Myelin Transcription Factor 1 Like
Chromosome: CHR2: 1792884 -2335045
Locus: 2p25.3
KIDINS220 Gene Summary
This gene encodes a transmembrane protein that is preferentially expressed in the nervous system where it controls neuronal cell survival, differentiation into exons and dendrites, and synaptic plasticity. The encoded protein interacts with membrane receptors, cytosolic signaling components, and cytoskeletal proteins, serving as a scaffold that mediates crosstalk between the neurotrophin pathway and several other intracellular signaling pathways. Aberrant expression of this gene is associated with the onset of various neuropsychiatric disorders and neurodegenerative diseases, including Alzheimer's disease. Naturally occurring mutations in this gene are associated with a syndrome characterized by spastic paraplegia, intellectual disability, nystagmus and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Gene Name: Kinase D Interacting Substrate 220
Chromosome: CHR2: 8868986 -8977755
Locus: 2p25.1
Gene Diseases
The KIDINS220 MYT1L Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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