KIAA1949-MDC1 Fusion FISH Probe
The KIAA1949-MDC1 Fusion FISH Probe is used to confirm a fusion of the KIAA1949 and MDC1 genes. The fusion of the KIAA1949 and MDC1 genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KIAA1949-MDC1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KIAA1949-MDC1-20-RERE | 20 (40 μL) | 200 μL |
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| KIAA1949-MDC1-20-REOR | 20 (40 μL) | 200 μL |
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| KIAA1949-MDC1-20-REGO | 20 (40 μL) | 200 μL |
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| KIAA1949-MDC1-20-REGR | 20 (40 μL) | 200 μL |
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| KIAA1949-MDC1-20-REAQ | 20 (40 μL) | 200 μL |
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| KIAA1949-MDC1-20-ORRE | 20 (40 μL) | 200 μL |
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| KIAA1949-MDC1-20-OROR | 20 (40 μL) | 200 μL |
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| KIAA1949-MDC1-20-ORGO | 20 (40 μL) | 200 μL |
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| KIAA1949-MDC1-20-ORAQ | 20 (40 μL) | 200 μL |
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| KIAA1949-MDC1-20-GORE | 20 (40 μL) | 200 μL |
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| KIAA1949-MDC1-20-GOOR | 20 (40 μL) | 200 μL |
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| KIAA1949-MDC1-20-GOGO | 20 (40 μL) | 200 μL |
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| KIAA1949-MDC1-20-GOGR | 20 (40 μL) | 200 μL |
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| KIAA1949-MDC1-20-GOAQ | 20 (40 μL) | 200 μL |
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| KIAA1949-MDC1-20-GRRE | 20 (40 μL) | 200 μL |
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| KIAA1949-MDC1-20-GROR | 20 (40 μL) | 200 μL |
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| KIAA1949-MDC1-20-GRGO | 20 (40 μL) | 200 μL |
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| KIAA1949-MDC1-20-GRGR | 20 (40 μL) | 200 μL |
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| KIAA1949-MDC1-20-GRAQ | 20 (40 μL) | 200 μL |
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| KIAA1949-MDC1-20-AQRE | 20 (40 μL) | 200 μL |
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| KIAA1949-MDC1-20-AQOR | 20 (40 μL) | 200 μL |
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| KIAA1949-MDC1-20-AQGO | 20 (40 μL) | 200 μL |
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| KIAA1949-MDC1-20-AQGR | 20 (40 μL) | 200 μL |
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| KIAA1949-MDC1-20-AQAQ | 20 (40 μL) | 200 μL |
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MDC1 Gene Summary
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008]
Gene Name: Mediator Of DNA Damage Checkpoint 1
Chromosome: CHR6_ssto_hap7: 1999890 -2017765
Locus: 6p21.33
Gene Diseases
The KIAA1949 MDC1 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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