KIAA1267-UNC45B Fusion FISH Probe
The KIAA1267-UNC45B Fusion FISH Probe is used to confirm a fusion of the KIAA1267 and UNC45B genes. The fusion of the KIAA1267 and UNC45B genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KIAA1267-UNC45B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KIAA1267-UNC45B-20-RERE | 20 (40 μL) | 200 μL |
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| KIAA1267-UNC45B-20-REOR | 20 (40 μL) | 200 μL |
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| KIAA1267-UNC45B-20-REGO | 20 (40 μL) | 200 μL |
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| KIAA1267-UNC45B-20-REGR | 20 (40 μL) | 200 μL |
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| KIAA1267-UNC45B-20-REAQ | 20 (40 μL) | 200 μL |
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| KIAA1267-UNC45B-20-ORRE | 20 (40 μL) | 200 μL |
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| KIAA1267-UNC45B-20-OROR | 20 (40 μL) | 200 μL |
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| KIAA1267-UNC45B-20-ORGO | 20 (40 μL) | 200 μL |
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| KIAA1267-UNC45B-20-ORAQ | 20 (40 μL) | 200 μL |
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| KIAA1267-UNC45B-20-GORE | 20 (40 μL) | 200 μL |
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| KIAA1267-UNC45B-20-GOOR | 20 (40 μL) | 200 μL |
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| KIAA1267-UNC45B-20-GOGO | 20 (40 μL) | 200 μL |
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| KIAA1267-UNC45B-20-GOGR | 20 (40 μL) | 200 μL |
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| KIAA1267-UNC45B-20-GOAQ | 20 (40 μL) | 200 μL |
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| KIAA1267-UNC45B-20-GRRE | 20 (40 μL) | 200 μL |
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| KIAA1267-UNC45B-20-GROR | 20 (40 μL) | 200 μL |
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| KIAA1267-UNC45B-20-GRGO | 20 (40 μL) | 200 μL |
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| KIAA1267-UNC45B-20-GRGR | 20 (40 μL) | 200 μL |
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| KIAA1267-UNC45B-20-GRAQ | 20 (40 μL) | 200 μL |
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| KIAA1267-UNC45B-20-AQRE | 20 (40 μL) | 200 μL |
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| KIAA1267-UNC45B-20-AQOR | 20 (40 μL) | 200 μL |
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| KIAA1267-UNC45B-20-AQGO | 20 (40 μL) | 200 μL |
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| KIAA1267-UNC45B-20-AQGR | 20 (40 μL) | 200 μL |
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| KIAA1267-UNC45B-20-AQAQ | 20 (40 μL) | 200 μL |
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UNC45B Gene Summary
This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Gene Name: Unc-45 Myosin Chaperone B
Chromosome: CHR17: 33474835 -33516364
Locus: 17q12
Gene Diseases
The KIAA1267 UNC45B Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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