KIAA0100-SEZ6 Fusion FISH Probe
The KIAA0100-SEZ6 Fusion FISH Probe is used to confirm a fusion of the KIAA0100 and SEZ6 genes. The fusion of the KIAA0100 and SEZ6 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KIAA0100-SEZ6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KIAA0100-SEZ6-20-RERE | 20 (40 μL) | 200 μL |
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| KIAA0100-SEZ6-20-REOR | 20 (40 μL) | 200 μL |
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| KIAA0100-SEZ6-20-REGO | 20 (40 μL) | 200 μL |
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| KIAA0100-SEZ6-20-REGR | 20 (40 μL) | 200 μL |
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| KIAA0100-SEZ6-20-REAQ | 20 (40 μL) | 200 μL |
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| KIAA0100-SEZ6-20-ORRE | 20 (40 μL) | 200 μL |
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| KIAA0100-SEZ6-20-OROR | 20 (40 μL) | 200 μL |
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| KIAA0100-SEZ6-20-ORGO | 20 (40 μL) | 200 μL |
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| KIAA0100-SEZ6-20-ORAQ | 20 (40 μL) | 200 μL |
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| KIAA0100-SEZ6-20-GORE | 20 (40 μL) | 200 μL |
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| KIAA0100-SEZ6-20-GOOR | 20 (40 μL) | 200 μL |
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| KIAA0100-SEZ6-20-GOGO | 20 (40 μL) | 200 μL |
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| KIAA0100-SEZ6-20-GOGR | 20 (40 μL) | 200 μL |
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| KIAA0100-SEZ6-20-GOAQ | 20 (40 μL) | 200 μL |
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| KIAA0100-SEZ6-20-GRRE | 20 (40 μL) | 200 μL |
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| KIAA0100-SEZ6-20-GROR | 20 (40 μL) | 200 μL |
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| KIAA0100-SEZ6-20-GRGO | 20 (40 μL) | 200 μL |
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| KIAA0100-SEZ6-20-GRGR | 20 (40 μL) | 200 μL |
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| KIAA0100-SEZ6-20-GRAQ | 20 (40 μL) | 200 μL |
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| KIAA0100-SEZ6-20-AQRE | 20 (40 μL) | 200 μL |
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| KIAA0100-SEZ6-20-AQOR | 20 (40 μL) | 200 μL |
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| KIAA0100-SEZ6-20-AQGO | 20 (40 μL) | 200 μL |
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| KIAA0100-SEZ6-20-AQGR | 20 (40 μL) | 200 μL |
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| KIAA0100-SEZ6-20-AQAQ | 20 (40 μL) | 200 μL |
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KIAA0100 Gene Summary
This gene was initially characterized in human as having high expression levels in breast carcinomas and breast cancer cell lines. This gene also has increased expression in prostrate cancer cells relative to normal prostrate tissues. Expression of this gene is negatively regulated by direct binding of the microRNA miR-195 to its 3' UTR. miR-195 has been shown to modulate the invasiveness of prostrate cancer cells and xenograft metastases by downgrading expression of this gene. In mouse, the protein encoded by this gene was identified as an antigen on acute monocytic leukemia cells. In human, alternative splicing results in multiple transcript variants encoding distinct isoforms; some of these isoforms are predicted to contain an RNA pol II promoter FMP27 protein domain and a Golgi-body-localization APT1 domain. [provided by RefSeq, Apr 2017]
Gene Name:
Chromosome: CHR17: 26941457 -26972177
Locus: 17q11.2
SEZ6 Gene Summary
The protein encoded by this gene is thought to contain five cysteine-rich motifs that are similar to sushi domains, as well as two domains similar to the amino terminal half of the CUB (for complement C1r/C1s, Uegf, Bmp1) domain. Mutations in this gene have been associated with febrile seizures. [provided by RefSeq, Jul 2016]
Gene Name: Seizure Related 6 Homolog
Chromosome: CHR17: 27281946 -27333081
Locus: 17q11.2
Gene Diseases
The KIAA0100 SEZ6 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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