KDM6A-DMD Fusion FISH Probe
The KDM6A-DMD Fusion FISH Probe is used to confirm a fusion of the KDM6A and DMD genes. The fusion of the KDM6A and DMD genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KDM6A-DMD-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KDM6A-DMD-20-RERE | 20 (40 μL) | 200 μL |
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| KDM6A-DMD-20-REOR | 20 (40 μL) | 200 μL |
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| KDM6A-DMD-20-REGO | 20 (40 μL) | 200 μL |
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| KDM6A-DMD-20-REGR | 20 (40 μL) | 200 μL |
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| KDM6A-DMD-20-REAQ | 20 (40 μL) | 200 μL |
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| KDM6A-DMD-20-ORRE | 20 (40 μL) | 200 μL |
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| KDM6A-DMD-20-OROR | 20 (40 μL) | 200 μL |
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| KDM6A-DMD-20-ORGO | 20 (40 μL) | 200 μL |
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| KDM6A-DMD-20-ORAQ | 20 (40 μL) | 200 μL |
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| KDM6A-DMD-20-GORE | 20 (40 μL) | 200 μL |
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| KDM6A-DMD-20-GOOR | 20 (40 μL) | 200 μL |
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| KDM6A-DMD-20-GOGO | 20 (40 μL) | 200 μL |
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| KDM6A-DMD-20-GOGR | 20 (40 μL) | 200 μL |
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| KDM6A-DMD-20-GOAQ | 20 (40 μL) | 200 μL |
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| KDM6A-DMD-20-GRRE | 20 (40 μL) | 200 μL |
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| KDM6A-DMD-20-GROR | 20 (40 μL) | 200 μL |
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| KDM6A-DMD-20-GRGO | 20 (40 μL) | 200 μL |
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| KDM6A-DMD-20-GRGR | 20 (40 μL) | 200 μL |
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| KDM6A-DMD-20-GRAQ | 20 (40 μL) | 200 μL |
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| KDM6A-DMD-20-AQRE | 20 (40 μL) | 200 μL |
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| KDM6A-DMD-20-AQOR | 20 (40 μL) | 200 μL |
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| KDM6A-DMD-20-AQGO | 20 (40 μL) | 200 μL |
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| KDM6A-DMD-20-AQGR | 20 (40 μL) | 200 μL |
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| KDM6A-DMD-20-AQAQ | 20 (40 μL) | 200 μL |
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DMD Gene Summary
This gene spans a genomic range of greater than 2 Mb and encodes a large protein containing an N-terminal actin-binding domain and multiple spectrin repeats. The encoded protein forms a component of the dystrophin-glycoprotein complex (DGC), which bridges the inner cytoskeleton and the extracellular matrix. Deletions, duplications, and point mutations at this gene locus may cause Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), or cardiomyopathy. Alternative promoter usage and alternative splicing result in numerous distinct transcript variants and protein isoforms for this gene. [provided by RefSeq, Dec 2016]
Gene Name: Dystrophin
Chromosome: CHRX: 31137344 -33357726
Locus: Xp21.2-p21.1
KDM6A Gene Summary
This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014]
Gene Name: Lysine Demethylase 6A
Chromosome: CHRX: 44732422 -44971845
Locus: Xp11.3
Gene Diseases
The KDM6A DMD Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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