KDM5C-HUWE1 Fusion FISH Probe
The KDM5C-HUWE1 Fusion FISH Probe is used to confirm a fusion of the KDM5C and HUWE1 genes. The fusion of the KDM5C and HUWE1 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KDM5C-HUWE1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KDM5C-HUWE1-20-RERE | 20 (40 μL) | 200 μL |
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| KDM5C-HUWE1-20-REOR | 20 (40 μL) | 200 μL |
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| KDM5C-HUWE1-20-REGO | 20 (40 μL) | 200 μL |
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| KDM5C-HUWE1-20-REGR | 20 (40 μL) | 200 μL |
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| KDM5C-HUWE1-20-REAQ | 20 (40 μL) | 200 μL |
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| KDM5C-HUWE1-20-ORRE | 20 (40 μL) | 200 μL |
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| KDM5C-HUWE1-20-OROR | 20 (40 μL) | 200 μL |
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| KDM5C-HUWE1-20-ORGO | 20 (40 μL) | 200 μL |
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| KDM5C-HUWE1-20-ORAQ | 20 (40 μL) | 200 μL |
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| KDM5C-HUWE1-20-GORE | 20 (40 μL) | 200 μL |
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| KDM5C-HUWE1-20-GOOR | 20 (40 μL) | 200 μL |
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| KDM5C-HUWE1-20-GOGO | 20 (40 μL) | 200 μL |
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| KDM5C-HUWE1-20-GOGR | 20 (40 μL) | 200 μL |
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| KDM5C-HUWE1-20-GOAQ | 20 (40 μL) | 200 μL |
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| KDM5C-HUWE1-20-GRRE | 20 (40 μL) | 200 μL |
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| KDM5C-HUWE1-20-GROR | 20 (40 μL) | 200 μL |
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| KDM5C-HUWE1-20-GRGO | 20 (40 μL) | 200 μL |
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| KDM5C-HUWE1-20-GRGR | 20 (40 μL) | 200 μL |
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| KDM5C-HUWE1-20-GRAQ | 20 (40 μL) | 200 μL |
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| KDM5C-HUWE1-20-AQRE | 20 (40 μL) | 200 μL |
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| KDM5C-HUWE1-20-AQOR | 20 (40 μL) | 200 μL |
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| KDM5C-HUWE1-20-AQGO | 20 (40 μL) | 200 μL |
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| KDM5C-HUWE1-20-AQGR | 20 (40 μL) | 200 μL |
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| KDM5C-HUWE1-20-AQAQ | 20 (40 μL) | 200 μL |
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KDM5C Gene Summary
This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Gene Name: Lysine Demethylase 5C
Chromosome: CHRX: 53220502 -53254604
Locus: Xp11.22
HUWE1 Gene Summary
This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic cognitive disability. [provided by RefSeq, Aug 2013]
Gene Name: HECT, UBA And WWE Domain Containing 1, E3 Ubiquitin Protein Ligase
Chromosome: CHRX: 53559062 -53713673
Locus: Xp11.22
Gene Diseases
The KDM5C HUWE1 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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