KDM5B-RASAL2 Fusion FISH Probe
The KDM5B-RASAL2 Fusion FISH Probe is used to confirm a fusion of the KDM5B and RASAL2 genes. The fusion of the KDM5B and RASAL2 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KDM5B-RASAL2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KDM5B-RASAL2-20-RERE | 20 (40 μL) | 200 μL |
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| KDM5B-RASAL2-20-REOR | 20 (40 μL) | 200 μL |
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| KDM5B-RASAL2-20-REGO | 20 (40 μL) | 200 μL |
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| KDM5B-RASAL2-20-REGR | 20 (40 μL) | 200 μL |
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| KDM5B-RASAL2-20-REAQ | 20 (40 μL) | 200 μL |
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| KDM5B-RASAL2-20-ORRE | 20 (40 μL) | 200 μL |
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| KDM5B-RASAL2-20-OROR | 20 (40 μL) | 200 μL |
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| KDM5B-RASAL2-20-ORGO | 20 (40 μL) | 200 μL |
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| KDM5B-RASAL2-20-ORAQ | 20 (40 μL) | 200 μL |
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| KDM5B-RASAL2-20-GORE | 20 (40 μL) | 200 μL |
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| KDM5B-RASAL2-20-GOOR | 20 (40 μL) | 200 μL |
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| KDM5B-RASAL2-20-GOGO | 20 (40 μL) | 200 μL |
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| KDM5B-RASAL2-20-GOGR | 20 (40 μL) | 200 μL |
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| KDM5B-RASAL2-20-GOAQ | 20 (40 μL) | 200 μL |
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| KDM5B-RASAL2-20-GRRE | 20 (40 μL) | 200 μL |
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| KDM5B-RASAL2-20-GROR | 20 (40 μL) | 200 μL |
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| KDM5B-RASAL2-20-GRGO | 20 (40 μL) | 200 μL |
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| KDM5B-RASAL2-20-GRGR | 20 (40 μL) | 200 μL |
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| KDM5B-RASAL2-20-GRAQ | 20 (40 μL) | 200 μL |
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| KDM5B-RASAL2-20-AQRE | 20 (40 μL) | 200 μL |
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| KDM5B-RASAL2-20-AQOR | 20 (40 μL) | 200 μL |
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| KDM5B-RASAL2-20-AQGO | 20 (40 μL) | 200 μL |
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| KDM5B-RASAL2-20-AQGR | 20 (40 μL) | 200 μL |
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| KDM5B-RASAL2-20-AQAQ | 20 (40 μL) | 200 μL |
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RASAL2 Gene Summary
This gene encodes a protein that contains the GAP-related domain (GRD), a characteristic domain of GTPase-activating proteins (GAPs). GAPs function as activators of Ras superfamily of small GTPases. The protein encoded by this gene is able to complement the defective RasGAP function in a yeast system. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Name: RAS Protein Activator Like 2
Chromosome: CHR1: 178062863 -178448648
Locus: 1q25.2
KDM5B Gene Summary
This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
Gene Name: Lysine Demethylase 5B
Chromosome: CHR1: 202696531 -202777549
Locus: 1q32.1
Gene Diseases
The KDM5B RASAL2 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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