KDM5B-ITPKB Fusion FISH Probe
The KDM5B-ITPKB Fusion FISH Probe is used to confirm a fusion of the KDM5B and ITPKB genes. The fusion of the KDM5B and ITPKB genes has been associated with Pheochromocytoma And Paraganglioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KDM5B-ITPKB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KDM5B-ITPKB-20-RERE | 20 (40 μL) | 200 μL |
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| KDM5B-ITPKB-20-REOR | 20 (40 μL) | 200 μL |
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| KDM5B-ITPKB-20-REGO | 20 (40 μL) | 200 μL |
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| KDM5B-ITPKB-20-REGR | 20 (40 μL) | 200 μL |
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| KDM5B-ITPKB-20-REAQ | 20 (40 μL) | 200 μL |
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| KDM5B-ITPKB-20-ORRE | 20 (40 μL) | 200 μL |
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| KDM5B-ITPKB-20-OROR | 20 (40 μL) | 200 μL |
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| KDM5B-ITPKB-20-ORGO | 20 (40 μL) | 200 μL |
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| KDM5B-ITPKB-20-ORAQ | 20 (40 μL) | 200 μL |
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| KDM5B-ITPKB-20-GORE | 20 (40 μL) | 200 μL |
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| KDM5B-ITPKB-20-GOOR | 20 (40 μL) | 200 μL |
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| KDM5B-ITPKB-20-GOGO | 20 (40 μL) | 200 μL |
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| KDM5B-ITPKB-20-GOGR | 20 (40 μL) | 200 μL |
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| KDM5B-ITPKB-20-GOAQ | 20 (40 μL) | 200 μL |
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| KDM5B-ITPKB-20-GRRE | 20 (40 μL) | 200 μL |
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| KDM5B-ITPKB-20-GROR | 20 (40 μL) | 200 μL |
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| KDM5B-ITPKB-20-GRGO | 20 (40 μL) | 200 μL |
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| KDM5B-ITPKB-20-GRGR | 20 (40 μL) | 200 μL |
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| KDM5B-ITPKB-20-GRAQ | 20 (40 μL) | 200 μL |
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| KDM5B-ITPKB-20-AQRE | 20 (40 μL) | 200 μL |
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| KDM5B-ITPKB-20-AQOR | 20 (40 μL) | 200 μL |
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| KDM5B-ITPKB-20-AQGO | 20 (40 μL) | 200 μL |
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| KDM5B-ITPKB-20-AQGR | 20 (40 μL) | 200 μL |
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| KDM5B-ITPKB-20-AQAQ | 20 (40 μL) | 200 μL |
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ITPKB Gene Summary
The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]
Gene Name: Inositol-trisphosphate 3-kinase B
Chromosome: CHR1: 226819390 -226926876
Locus: 1q42.12
KDM5B Gene Summary
This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
Gene Name: Lysine Demethylase 5B
Chromosome: CHR1: 202696531 -202777549
Locus: 1q32.1
Gene Diseases
The KDM5B ITPKB Fusion has been associated with the following diseases:
| Disease Name |
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| Pheochromocytoma And Paraganglioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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