KDM5A-RAE1 Fusion FISH Probe
The KDM5A-RAE1 Fusion FISH Probe is used to confirm a fusion of the KDM5A and RAE1 genes. The fusion of the KDM5A and RAE1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KDM5A-RAE1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KDM5A-RAE1-20-RERE | 20 (40 μL) | 200 μL |
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| KDM5A-RAE1-20-REOR | 20 (40 μL) | 200 μL |
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| KDM5A-RAE1-20-REGO | 20 (40 μL) | 200 μL |
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| KDM5A-RAE1-20-REGR | 20 (40 μL) | 200 μL |
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| KDM5A-RAE1-20-REAQ | 20 (40 μL) | 200 μL |
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| KDM5A-RAE1-20-ORRE | 20 (40 μL) | 200 μL |
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| KDM5A-RAE1-20-OROR | 20 (40 μL) | 200 μL |
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| KDM5A-RAE1-20-ORGO | 20 (40 μL) | 200 μL |
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| KDM5A-RAE1-20-ORAQ | 20 (40 μL) | 200 μL |
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| KDM5A-RAE1-20-GORE | 20 (40 μL) | 200 μL |
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| KDM5A-RAE1-20-GOOR | 20 (40 μL) | 200 μL |
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| KDM5A-RAE1-20-GOGO | 20 (40 μL) | 200 μL |
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| KDM5A-RAE1-20-GOGR | 20 (40 μL) | 200 μL |
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| KDM5A-RAE1-20-GOAQ | 20 (40 μL) | 200 μL |
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| KDM5A-RAE1-20-GRRE | 20 (40 μL) | 200 μL |
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| KDM5A-RAE1-20-GROR | 20 (40 μL) | 200 μL |
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| KDM5A-RAE1-20-GRGO | 20 (40 μL) | 200 μL |
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| KDM5A-RAE1-20-GRGR | 20 (40 μL) | 200 μL |
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| KDM5A-RAE1-20-GRAQ | 20 (40 μL) | 200 μL |
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| KDM5A-RAE1-20-AQRE | 20 (40 μL) | 200 μL |
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| KDM5A-RAE1-20-AQOR | 20 (40 μL) | 200 μL |
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| KDM5A-RAE1-20-AQGO | 20 (40 μL) | 200 μL |
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| KDM5A-RAE1-20-AQGR | 20 (40 μL) | 200 μL |
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| KDM5A-RAE1-20-AQAQ | 20 (40 μL) | 200 μL |
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KDM5A Gene Summary
This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression. [provided by RefSeq, Aug 2013]
Gene Name: Lysine Demethylase 5A
Chromosome: CHR12: 389222 -498620
Locus: 12p13.33
RAE1 Gene Summary
Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Ribonucleic Acid Export 1
Chromosome: CHR20: 55926144 -55953519
Locus: 20q13.31
Gene Diseases
The KDM5A RAE1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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