KDM4C-RFX3 Fusion FISH Probe
The KDM4C-RFX3 Fusion FISH Probe is used to confirm a fusion of the KDM4C and RFX3 genes. The fusion of the KDM4C and RFX3 genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KDM4C-RFX3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KDM4C-RFX3-20-RERE | 20 (40 μL) | 200 μL |
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| KDM4C-RFX3-20-REOR | 20 (40 μL) | 200 μL |
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| KDM4C-RFX3-20-REGO | 20 (40 μL) | 200 μL |
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| KDM4C-RFX3-20-REGR | 20 (40 μL) | 200 μL |
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| KDM4C-RFX3-20-REAQ | 20 (40 μL) | 200 μL |
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| KDM4C-RFX3-20-ORRE | 20 (40 μL) | 200 μL |
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| KDM4C-RFX3-20-OROR | 20 (40 μL) | 200 μL |
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| KDM4C-RFX3-20-ORGO | 20 (40 μL) | 200 μL |
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| KDM4C-RFX3-20-ORAQ | 20 (40 μL) | 200 μL |
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| KDM4C-RFX3-20-GORE | 20 (40 μL) | 200 μL |
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| KDM4C-RFX3-20-GOOR | 20 (40 μL) | 200 μL |
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| KDM4C-RFX3-20-GOGO | 20 (40 μL) | 200 μL |
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| KDM4C-RFX3-20-GOGR | 20 (40 μL) | 200 μL |
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| KDM4C-RFX3-20-GOAQ | 20 (40 μL) | 200 μL |
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| KDM4C-RFX3-20-GRRE | 20 (40 μL) | 200 μL |
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| KDM4C-RFX3-20-GROR | 20 (40 μL) | 200 μL |
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| KDM4C-RFX3-20-GRGO | 20 (40 μL) | 200 μL |
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| KDM4C-RFX3-20-GRGR | 20 (40 μL) | 200 μL |
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| KDM4C-RFX3-20-GRAQ | 20 (40 μL) | 200 μL |
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| KDM4C-RFX3-20-AQRE | 20 (40 μL) | 200 μL |
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| KDM4C-RFX3-20-AQOR | 20 (40 μL) | 200 μL |
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| KDM4C-RFX3-20-AQGO | 20 (40 μL) | 200 μL |
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| KDM4C-RFX3-20-AQGR | 20 (40 μL) | 200 μL |
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| KDM4C-RFX3-20-AQAQ | 20 (40 μL) | 200 μL |
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RFX3 Gene Summary
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013]
Gene Name: Regulatory Factor X3
Chromosome: CHR9: 3224646 -3525983
Locus: 9p24.2
KDM4C Gene Summary
This gene is a member of the Jumonji domain 2 (JMJD2) family. The encoded protein is a trimethylation-specific demethylase, and converts specific trimethylated histone residues to the dimethylated form. This enzymatic action regulates gene expression and chromosome segregation. Chromosomal aberrations and changes in expression of this gene may be found in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Gene Name: Lysine Demethylase 4C
Chromosome: CHR9: 6757640 -7175648
Locus: 9p24.1
Gene Diseases
The KDM4C RFX3 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Clear Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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